慢性脑供血不足患者颈总动脉检测及高压氧对肱动脉内皮依赖性舒张功能影响的评价  

Detection of carotid artery and evaluation of the effect of hyperbaric oxygen on endothelial dependent dilation function of brachial artery in patients with chronic cerebral circulation insufficiency

作　　者：赵夏夏[1] 张琦[1] 郑宇浩[2] 杨国嵘[1] 种晓琴[1] 吉新雁[1] 

机构地区：[1]解放军第一医院,甘肃兰州730030 [2]成都电子科技大学生命科学与技术学院生物医学工程系

出　　处：《西北国防医学杂志》2011年第6期404-406,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：兰州军区医药卫生科研基金资助项目(LXH2007018)

摘　　要：目的:检测慢性脑供血不足(CCCI)患者颈总动脉并评价高压氧对其肱动脉内皮依赖性舒张功能(EDD)的影响。方法:用彩色多普勒超声检测62例患者颈总动脉内中膜厚度(IMT)和斑块情况,并分别于高压氧治疗前及治疗10 d后检测肱动脉EDD值,同时测定其血清NO和ET水平。结果:与正常人群(0.65±0.12)mm比较,所有CCCI患者IMT均增厚(P<0.05);所有患者颈总动脉斑块检出率为74.19%(46/62);治疗后EDD和血清NO较治疗前均有显著升高(P<0.05,P<0.01)。结论:CCCI患者有较高的颈总动脉斑块检出率;彩色多普勒超声可客观的评价高压氧对肱动脉内皮依赖性舒张功能(EDD)的影响。Objective：To detect carotid artery and evaluate the effect of hyperbaric oxygen on endothelial dependent dilation（EDD） function of brachial artery in patients with chronic cerebral circulation insufficiency（CCCI）.Methods：Intima-media thickness（IMT） and plaque of carotid artery of 62 cases were detected by color Doppler ultrasound.EDD of brachial artery,serum levels of NO and ET of the two groups were detected before and 10 days after hyperbaric oxygen therapy.Results：Compared with normal people（0.65±0.12mm）,IMT in patients with CCCI was increased（P〈0.05）.Frequency of plaque of carotid artery was 74.19%（46/62）.EDD of brachial artery and serum levels of NO of the two groups increased significantly after treatment compared with that before therapy（P〈0.05,P〈0.01）.Conclusion：There exists a high frequency of plaque of carotid artery in patients with CCCI.The effect of hyperbaric oxygen on endothelial dependent dilation function of brachial artery in patients with CCCI could be evaluated objectively by color Doppler ultrasound.

关 键 词：超声波诊断 慢性脑供血不足 高压氧 内皮依赖性舒张功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]