肺癌患者七项血清学指标测定的评价  

Apprasial of the Diagnostic Values of Seven Serologic Markers in Lung Cancer Patients

作　　者：齐法莲[1] 杨道理[1] 安娟[1] 黄象燕 徐军[1] 彭立义[1] 

机构地区：[1]济南军区总医院免疫科,250031

出　　处：《放射免疫学杂志》2000年第2期65-67,共3页Journal of Radioimmanology

摘　　要：目的 :对血清SE -SLT、LN、HA、CEA、NSE、AIF、CA242进行测定 ,旨在筛选实用的肺癌诊断标志物 ,提高阳性检出率。方法 :分别采用ELISA、RIA和IRMA法对肺癌组、慢性支气管炎(CAB)组及正常对照组进行七项指标测定 ,并从敏感性、特异性、假阳性、假阴性等方面进行比较分析。结果 :肺癌组七项指标含量均高于正常对照组(P<0.01),SE -SLT敏感性最高(81.6 %) ,假阴性率最低(18.4%) ;CA242特异性最强(96.0%) ,假阳性率最低(4.0 %)。结论 :在常规进行CEA或NSE测定同时检测SE -SLT和CA242是优势互补诊断肺癌的较好的组合模式。Objective To select some practically useful items with higher positive rates from the currently applied seven serologic markers (SE-SLT、 LN、 HA、 CEA、 NSE、 AIF、 CA242) for diagnosis of lung cancer. Methods These seven markers were detected by ELISA, RIA and IRMA in lang cancer patients (273), CAB patients (179) and 193 controls. Sensitivity, specificity, false positivity and false negativity were compared and analyzed. Results The levels of all seven markers in lung cancer patients were higher than those in controls (P<0.01). The sensitivity of SE-SLT was the highest (81.6%) with lowest falsenegativity (18.4%). The specificity of CA242 was highest (96%) with lowest false positivity (4.0%). Conclusions Simultaneous SE-SLT and CA242 detection with routine CEA and NSE detection is a good model for diagnosis of lung cancer.

关 键 词：肺癌 可溶性E-选择素 CA-242 癌胚抗原 

分 类 号：R734.2[医药卫生—肿瘤]