焦化工人癌症高发与超氧化物歧化酶异常的研究  

DISCUSSION ON CANCER AND SUPEROXIDE DISMUTASE OF WORKERS IN COKE PLANT

作　　者：史天良[1] 刘维兰[1] 韩小友[1] 郑启英[1] 赵丽[2] 马克蓉[1] 王跃华[2] 

机构地区：[1]山西省肿瘤研究所,山西太原030013 [2]山西省肿瘤医院,山西太原030013

出　　处：《肿瘤研究与临床》2000年第2期101-102,共2页Cancer Research and Clinic

摘　　要：目的 :研究焦化工人癌症高发与其体内超氧化物歧化酶的相关性。方法 :对某焦化厂职工进行恶性肿瘤死亡的回顾性调查 ;检测焦化工人血中超氧化物歧化酶的活性和脂质过氧化产物的含量。结果 :焦化厂职工恶性肿瘤的死亡率高于对照组 (P<0 .0 1) ,炼焦工人肺癌死亡率随在该环境中工作时间的增加呈上升趋势。炼焦工人血中的超氧化物歧化酶的活性高于对照组 (P<0 .0 1) ,脂质过氧化产物含量两组相近。结论 :焦化职工恶性肿瘤的死亡率高于对照组是由于煤焦烟气中的有害物质长期侵蚀受累人群 ,骨髓干细胞的基因表达紊乱所致。Objective:To study the relationshiop between cancer and superoxide dismutase of the coke workers.Methods:The cancer mortality of the coke workers was studied retrospectively.Superoxide dismutase and lipid peroxide was used for detection of the coke workers.Results:The cancer mortality was obviously higher in the coke workers than in normal control(P<0.01).The rate of lung cancer rose with the increasing of working times.The result showed that superoxide dismutase activity of the coke workers was higher than normal control(P<0.01), and lipid peroxide concertration was not different between coke workers and normal control.Conclusion:The change of enzyme may be related to the disorder of gene expression in stem cell.

关 键 词：炼焦工人 癌症 超氧化物歧化酶 脂质过氧化产物 

分 类 号：R730.231[医药卫生—肿瘤]