鸦胆子提取物对S_(180)小鼠抗肿瘤作用的实验研究  

Experimental study on the anticancer effect of Extract of Brucea javanica on mice of S_(180)

作　　者：田桂英[1] 谢荣辉[2] 

机构地区：[1]湖南省保靖县人民医院药剂科,湖南保靖416500 [2]河北华北油田总医院药剂科,河北任丘062552

出　　处：《肿瘤药学》2011年第3期220-222,共3页Anti-Tumor Pharmacy

摘　　要：目的研究鸦胆子提取物对小鼠移植性肿瘤S180的抑制作用。方法建立小鼠腋下S180实体瘤模型,观察不同剂量鸦胆子提取物对小鼠抑瘤率及对免疫器官的影响;建立小鼠S180腹水瘤模型,观察不同剂量鸦胆子提取物对小鼠生存期的影响。结果鸦胆子提取物中、高剂量能明显抑制S180实体瘤的生长(P<0.05);抑瘤率分别为20.4%和24.6%。鸦胆子提取物低、中剂量可以延长S180腹水瘤小鼠的生存期(P<0.05),延长率为21%和18.5%。结论鸦胆子提取物有一定抗肿瘤的作用。Objective To study inhibitory effects of Brucea javanica extract on mice transplanted S180 tu- mor. Method The S180 solid tumor model in mouse armpit was constructed to study the inhibition rate of different do2ses of Bmcea javanica extract on the tumor and the influence on the immune organs; The establishment of Sis0 ascites model was constnlcted to explore the effect of Brucea javanica extract on the survival rate of mice at dif- ferent dose. Results Javanica extract, can inhibit the growth of S180 sohd tumors at high dose （P〈0.05） Inhibition rates were 20.4% and 24.6% respectively. The survival of mice can be extended, with 21% and 18.5%, via Java- nica extract treatment. Conclusion Extract of Brucea javanica has certain anti-tunaor effect.

关 键 词：鸦胆子提取物 S180实体瘤 S180腹水瘤 

分 类 号：R730.52[医药卫生—肿瘤] R285.5[医药卫生—临床医学]