脑血管畸形患者VEGF、LM及Ki67的表达及临床意义  

The expressions and its significance of VEGF,LM,Ki67 in cerebral vascular malformation

作　　者：杨延莉[1] 魏茂富[2] 刘镜文[2] 

机构地区：[1]广东省东莞市虎门医院内三科,广东东莞523900 [2]广东省东莞市虎门医院病理科,广东东莞523900

出　　处：《中国现代医生》2012年第9期92-93,共2页China Modern Doctor

摘　　要：目的观察脑血管畸形(CVM)患者血管内皮生长因子(VEGF)、层粘连蛋白(LM)及Ki67的阳性表达,研究VEGF、LM及Ki67在脑血管畸形患者中表达的临床意义。方法应用免疫组织化学方法检测70例脑血管畸形患者标本中VEGF、LM及Ki67蛋白的表达。结果 70例脑血管畸形患者中,VEGF、LM、Ki67阳性表达率分别为64.3%、75.7%及80.0%;22例正常脑组织血管中VEGF、LM及Ki67阳性表达率分别为31.8%、50.0%、45.5%,两两比较差异均有统计学意义(P<0.05)。结论 VEGF、LM及Ki67均参与了CVM的发生发展。Objective To investigate the expression of VEGF, LM, Ki67 in cerebral vascular malformation （CVM） and find out its significance. Methods The expression of VEGF, LM, Ki67 were detected by the immunohistochemistry staining. Results In 70 cases of CVM, positive expression rates of VEGF, LM, Ki67 were 64.3%, 75.7%, 80.0% and in 22 normal brain tissues were 31.8%, 50.0%, 45.5%, respectively. The positive rates were higher in CVM than in normal brain tissues （P 〈 0.05）. Conclusion VEGF, LM and Ki67 might take part in the pathogenesis of CVM development and progress.

关 键 词：血管内皮生长因子 层粘连蛋白 KI67 脑血管畸形 免疫组化 

分 类 号：R743.4[医药卫生—神经病学与精神病学]