CXCR4基因在食管鳞癌患者术后早期复发转移中表达的研究  

The Expression of CXCR4 Gene in Esophageal Squamous Cell Carcinoma Patients with Early Postoperative Recurrence and Metastasis

作　　者：刘永煜[1] 杨成良[1] 乔雪[1] 孙麒翔[1] 

机构地区：[1]辽宁省肿瘤医院,辽宁省食管癌重点实验室,辽宁沈阳110042

出　　处：《中国肿瘤》2012年第4期306-308,共3页China Cancer

基　　金：辽宁省医学高峰建设工程项目(2010079);辽宁省食管癌重点实验建设专项基金(2011-20);辽宁省“百千万人才工程”资助项目(2009-390);辽宁省医学重点专科建设项目(200824)

摘　　要：[目的]评价CXCR4基因在食管鳞癌术后早期复发转移患者中的表达。[方法]选择43例术后早期复发转移食管鳞癌标本、46例术后1年内未发生复发转移食管鳞癌标本和17例正常食管组织标本,应用RT-PCR和Western Blot方法检测标本中CXCR4基因mRNA和蛋白的表达情况。[结果]与术后1年内未发生复发转移食管鳞癌组织和正常食管组织相比,术后早期复发转移食管鳞癌标本CXCR4基因的mRNA和蛋白的表达存在明显上调,差异有统计学意义(P<0.05)。[结论]在食管鳞癌组织中CXCR4基因表达的改变可能与肿瘤复发转移有关。[Purpose j To investigate the expression of CXCR4 gene in esophageal squamous cell patients with early postoperative recurrence and metastasis. [Methodsl Forty-three tissue samples with early postoperative recurrence and metastasis of esophageal squamous cell carcinoma, 46 tis- sue samples with postoperative esophageal squamous cell carcinoma without recurrence or metas- tasis within one year, and 17 samples with normal esophageal tissue were enrolled, mRNA and protein of CXCR4 expressions were detected by RT-PCR and western blot. [Results] Compared to postoperative esophageal squamons cell eareinoma without reeuta^nce within one year and nor- mal esophageal tissues, CXCR4 mRNA and protein expression in case with early postoperative recurrence and metastasis of esophageal squamous cell carcinoma tissue samples were up-regulat- ed with statistically different （P〈0.05）. [Conclusions] CXCR4 in esophageal squamous cell carci- noma gene expression changes may be related to tumor recurrence and metastasis.

关 键 词：食管癌 复发 转移 CXCR4 

分 类 号：R735.1[医药卫生—肿瘤]