他克莫司软膏治疗激素依赖性皮炎疗效观察  

Clinical efficacy of topical tacrolimus ointment in treating corticosteroid dependent dermatitis

作　　者：马静[1] 温炬[1] 冯洁莹[1] 郑荣昌[1] 周容[1] 李欢玉[1] 

机构地区：[1]广东省第二人民医院皮肤科,广州510317

出　　处：《陕西医学杂志》2012年第2期226-227,共2页Shaanxi Medical Journal

摘　　要：目的:观察他克莫司软膏治疗激素依赖性皮炎的临床疗效和安全性。方法:将68例患者随机分为两组,治疗组外用0.1%他克莫司软膏,每日两次;对照组外用氧化锌软膏,每日两次,并口服盐酸西替利嗪分散片10mg/d,4周为1疗程。结果:治疗组有效率97.06%,对照组有效率61.76%,两组治愈率和有效率比较,差异有统计学意义(P<0.05)。结论:他克莫司软膏治疗激素依赖性皮炎疗效好、副作用少。Objective：To investigate the clinical efficacy and safety of Topical Tacrolimus ointment 0.1% in the treatment of patients with corticosteroid dependent dermatitis.Methods：68 patients were divided into 2 groups randomly.Group 1 was treated with Tacrolimus ointment 0.1% 2 times a day for 4 weeks.Group 2 was treated with zinc oxide ointment 2 times a day for 4 weeks.At the same time the patients of group 2 oral cetirizine 10mg once a day.Results：All patients completed the whole course of treatment.After treatment the effective rate of group 1 and group 2 were 97.06% and 61.76% respectively.There was significant statistic difference in clinical efficacy（P〈0.05）.Conclusion： Topical Tacrolimus 0.1% is a better choice for patients with corticosteroid dependent dermatitis because of better clinical efficacy and safety.

关 键 词：皮炎/药物疗法 他克莫司/治疗应用 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]