新辅助化疗对乳腺癌增殖性抗原Ki-67和凋亡蛋白酶3的影响  

The effects of neoadjuvant chemotherapy on Ki-67 and Caspase-3 expression in breast cancer

作　　者：张殿龙[1] 曹铭谦[1] 王晓兰[1] 姚永强[1] 方红[1] 解继平[1] 程晓宇[1] 

机构地区：[1]大连大学附属中山医院乳腺甲状腺外科,大连辽宁116001

出　　处：《中国医药导报》2012年第11期91-93,共3页China Medical Herald

基　　金：辽宁省大连市卫生局立项课题

摘　　要：目的 探讨乳腺癌新辅助化疗（NAC）后增殖性抗原Ki-67（Ki-67）和凋亡蛋白酶3（Caspase-3）的变化及临床意义.方法 随机选择我院2010年1月~2011年6月进行NAC治疗的51例乳腺癌患者,采用免疫组化SP法分别检测NAC前后Ki-67和Caspase-3在乳腺癌组织中的表达水平.结果 NAC后Ki-67阳性率显著下降,差异有统计学意义（P ＜ 0.05）;而在NAC前后Caspase-3的变化差异无统计学意义（P ＞ 0.05）.NAC前Ki-67阳性者对化疗的有效率为76.9%,差异有统计学意义（P ＜ 0.05）;NAC前Caspase-3阴性者对化疗的有效率为74.1%,差异无统计学意义（P ＞ 0.05）.结论 Ki-67的表达状态影响NAC的疗效;Caspase-3的表达状态不影响NAC的疗效.Ki-67表达状态可能成为NAC敏感性的预测指标.Objective To explore the changes and clinical significance of Ki-67 and Caspase-3 expressions in breast cancer after neoadjuvant chemotherapy.Methods 51 patients diagnosed with breast cancer from January 2010 to June 2011 were included in our study.Ki-67 and Caspase-3 were examined by immunohistochemical staining before and after NAC.Results The positive rate of Ki-67 decreased after NAC,there was statistical significance（P 0.05）,but there was no statistical significance of Caspase-3 changes after NAC（P 0.05）.The effective rate of NAC was 76.9% in the patients who were Ki-67 positive before treatment,the difference was statistically significant（P 0.05）.The effective rate of NAC was 74.1% in the patients who were Caspase-3 positive before treatment,the difference was not statistically significant（P 0.05）.Conclusion The expression of Ki-67 affect the efficacy of NAC.The expression of Caspase-3 does not affect the efficacy of NAC.Ki-67 expression status maybe a predictor of NAC sensitivity.

关 键 词：新辅助化疗 乳腺癌 KI-67 CASPASE-3 

分 类 号：R737.3[医药卫生—肿瘤]