丙戊酸钠治疗预防偏头痛有效性与安全性的Meta分析  

Meta-analysis of the efficacy and safety of Sodium Valproate in the treatment and prevention of migraine

作　　者：胡发明[1] 黄知秀[2] 张静[2] 

机构地区：[1]湖北省荆州市第一人民医院药学部,湖北荆州434000 [2]湖北省荆州市第一人民医院神经内科,湖北荆州434000

出　　处：《中国医药导报》2012年第11期94-96,共3页China Medical Herald

摘　　要：目的了解丙戊酸钠治疗偏头痛有效性及安全性的差异。方法应用Meta分析对纳入文献研究中丙戊酸钠与其他治疗偏头痛的药物在治疗预防偏头痛有效性上进行同质性检验及合并效应量的估计。并对不良反应进行描述性分析。结果在托吡酯亚组中,χ2=0.13,df=1,P=0.72>0.05,该研究具有同质性,应用固定效应模型分析,统计结果OR=0.96,95%CI[0.50,1.84],Z=0.12,P=0.91>0.05,二者无显著差异;在非托吡酯亚组中,χ2=2.15,df=3,P=0.54>0.05,研究具有同质性,应用固定效应模型分析,统计结果 OR=4.83,95%CI[2.51,9.28],P<0.000 01,二者有显著差异,治疗组优于对照组。结论丙戊酸钠在治疗预防偏头痛上与对照组比较在疗效及不良反应上有显著差异,在治疗预防偏头痛上是安全有效的。Objective To understand the differences in efficacy and safety of Sodium Valproate in the treatment of migraine.Methods Homogeneity test and estimation of combined effect of Sodium Valproate and other treatments in the treatment and prevention of migraine as demonstrated in the included literature were performed with Meta-analysis.And descriptive analysis of adverse reactions was also performed.Results In the topiramate subgroups,χ2 = 0.13,df = 1 and P = 0.720.05.The study is of homogeneity,using a fixed effects model analysis.And the statistical results were： OR = 0.96,95% CI was [0.50,1.84],Z = 0.12 and P = 0.910.05,showing non-significant differences between the two groups;in non-care pyrazole ester sub-group,χ2 = 2.15,df = 3,P = 0.540.05.The study is of homogeneity,using a fixed effects model analysis.And the statistical results were： OR = 4.83,95% CI was [2.51,9.28],P 0.000 01,showing significantly better treatment results in the treatment group than in the control group.Conclusion Sodium Valproate shows significant differences in efficacy and adverse reactions in the treatment and prevention of migraine compared with the control group,thus is an effective and safe treatment and prevention of migraine.

关 键 词：丙戊酸钠 偏头痛 有效性 安全性 META分析 

分 类 号：R747.2[医药卫生—神经病学与精神病学]