Smad2与TGF-β1基因在胰腺癌中的表达及临床意义(英文)  

Expression of Smad2 and TGFβ 1 in Human Pancreatic Carcinoma Tissues and its Signifiance

作　　者：潘新亭[1] 王新生[1] 王正滨[1] 朱青云[1] 韩燕[1] 

机构地区：[1]青岛大学医学院附属医院,山东青岛266003

出　　处：《现代生物医学进展》2012年第6期1122-1125,共4页Progress in Modern Biomedicine

基　　金：中国博士后科学基金面上项目(2011M500697)

摘　　要：目的:通过检测Smad2与TGF-β1基因在胰腺癌中的表达,初步探讨它们与胰腺癌临床病理的关系。方法:采用免疫组织化学pv-9000法检测50例胰腺癌组织和10例正常胰腺组织中Smad2与TGF-β1的表达情况,并分析其与胰腺癌临床病理的相关性。结果:Smad2与TGF-β1在胰腺癌组织中的表达水平显著高于正常胰腺组织,两组之间存在显著差异(P<0.05)。在胰腺癌组织中,Smad2与TGF-β1的表达在胰腺癌不同分期中存在显著差异(P<0.05)。结论:Smad2与TGF-β1在胰腺癌中高表达,二者联合可作为反映胰腺癌临床分期的生物学指标。Objective： To investigate relationships of the expression of Smad2,TGFβ 1 in the tissues of pancreatic adenocarcinoma and normal pancreas and the clinicopathological parameters of pancreatic adenocarcinomas.Methods： The expressions of the Smad2,TGFβ 1 in formalin-fixed paraffin embedded samples of 50 patients and 10 normal pancreatic tissues were detected by pancreatic adenocarcinoma.The ages,gender,tumor size,location,degree of differentiation and stage were recorded.Results： The expression of Smad2,TGFβ 1 was higher in pancreatic adenocarcinoma than that in the normal pancreatic parenchyma.There were significant differences between the two groups（P0.05）.In pancreatic adenocarcinoma,the expression of Smad2,TGFβ 1 in different TNM staging were significantly different（P0.05）.Conclusions： The expression of Smad2,TGFβ 1 in pancreatic adenocarcinoma was higher than that in the normal pancreatic parenchyma.The expression of Smad2,TGFβ 1 in pancreatic cancer tissues was related to the tumor stage.

关 键 词：胰腺癌 SMAD2 TGF-Β1 免疫组织化学 

分 类 号：R735.9[医药卫生—肿瘤]