EB病毒LMP1在肿瘤研究中的进展  

Advancement of Epstein-Barr Virus-Encoded LMP1 in Tumor

作　　者：唐微[1] 朱建思[1] 

机构地区：[1]南华大学医学院肿瘤研究所,湖南衡阳421001

出　　处：《现代生物医学进展》2012年第7期1394-1397,1390,共5页Progress in Modern Biomedicine

摘　　要：EB病毒(Epstein-Barr virus,EBV)是具有致瘤潜能的疱疹病毒,与多种恶性肿瘤的发生相关。EB病毒编码的潜伏性膜蛋白1(Latent membrane protein-1,LMP1)作为其主要的致瘤蛋白,能通过细胞内多种信号传导通路,调节和控制细胞的生长、增殖、分化、迁移与凋亡,从而在癌变的发生和发展过程中发挥重要的作用。本文主要就LMP1的结构、生物学功能、介导的信号通路及其与肿瘤关系的相关进展做一阐述。Epstein-Barr virus is a kind of herpes virus that has oncogenic potential and is related to the tumor genesis process of various malignancy.Epstein-Barr virus-encoded LMP1 plays an important role in the pathogenesis and development of cancer,which as the main oncogenic protein of EBV,through a variety of intracellular signal transduction pathways to regulate and control cell growth,proliferation,differentiation,migration and apoptosis.This article mainly reviews its structure,biological function,signaling pathway and the related progress with tumor.

关 键 词：EB病毒 潜伏性膜蛋白1 肿瘤 

分 类 号：R730.231[医药卫生—肿瘤]