进展期结直肠癌淋巴转移规律的临床研究  

CLINICAL STUDIES ON THE RULE OF LYMPHATIC METASTASIS FOR ADVANCED COLORECTAL CANCER

作　　者：高友福[1] 姜波健[1] 孙荣勋[1] 沈浩[1] 涂长龄[1] 

机构地区：[1]上海市静安区中心医院普外科,上海200040

出　　处：《中国普外基础与临床杂志》2000年第1期27-29,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　研究进展期结直肠癌淋巴结转移规律， 评价手术根治程度。方法　分析１１４ 例结直肠癌行扩大的Ｄ３ 式根治术后淋巴结１ ００５ 个， 按肿瘤旁、肠管纵轴和中枢方向淋巴结分组分站。结果　肿瘤旁、肠管纵轴方向淋巴结转移率、转移度和阳性淋巴结分布率分别为４３ ．９ ％ 、３７ ．２ ％ 和５８ ．９ ％ 及３２ ．５ ％ 、１５ ．９ ％ 和１７ ．５ ％ ， 口侧端有淋巴结转移大多在１０ ｃｍ 以内， 而直肠癌肛侧端距肿瘤２ ．０ ｃｍ 以内转移率为５ ．５ ％ ， ２ ～４ ｃｍ 处未见转移。中枢方向系膜、系膜血管根部淋巴结转移率和转移度分别为１９ ．３ ％ 和１６ ．６ ％ 及１０ ．５ ％ 和７ ．８ ％ ； 中枢方向及肠管纵轴方向阳性淋巴结分布率分别为２３ ．５ ％ 和１７ ．５ ％ 。直肠乙状结肠部癌 （Ｒｓ） 、上部直肠癌（ Ｒａ） 和下部直肠癌 （Ｒｂ） 侧方淋巴结转移率分别为０ ％ 、８ ．７ ％ 和１２ ．５ ％ 。结论　进展期结直肠癌有向肠管纵轴和中枢方向转移； 跳跃式转移是一特点。低位直肠癌离肛缘６ ｃｍ 以内， 浸润深度为ｐＴ３ 及ｐＴ４ 时， 其侧方淋巴结转移率较高。结肠癌宜行Ｄ３ 式淋巴廓清， 直肠癌主张系膜下动脉根部结扎，Objective To study the rule of lymphatic metastasis and to evaluate the extent of curative resection in advanced colorectal cancer. Methods One thousand and five lymph nodes from 114 consecutive patients with colorectal cancer underwent extended D 3 resection were analyzed and classified as peritumor, longitudinal, and upward spread distribution. Results The metastatic rate and incidence of lymph node metastasis in peritumor, longitudinal as well as upward spread (N 2 and N 3) was 43.9% and 37.2%, 32.5% and 15.9% as well as 29.8% (19.3% and 10.5%) and 12.1% (16.6% and 7.8%) respectively. The distribution rate of metastatic lymph nodes was 17.5% and 23.5% in the longitudinal and upward spread respectively. In the longitudinal spread, most of lymph node metastasis was seen within 10 cm. Within 2 cm on the anal side in rectal cancer, the metastasis rate was 5.5%, and there was no metastasis in 2-4 cm. The lateral metastasis rate was 0%, 8.7% and 12.5% in the rectosigmoid (Rs), upper rectum (Ra) and lower rectum (Rb) respectively. Conclusion Advanced colorectal cancer tend to metastasize to longitudinal and upward lymph nodes. Jump metastasis is also a feature. In the lower rectal cancer within 6 cm from the anal verge or beyond pT 3, there is a high risk of lateral metastasis. Extended D 3 radical resection is necessary for colic cancer, but high ligation of the inferior mesenteric artery root as well as lateral lymphadenectomy and total mesenteric excision should also be performed for rectal cancer. There is no residual tumor tissue in the anastomosis when the excision distance is beyond 2 cm from the anal margin in rectal cancer.

关 键 词：淋巴转移 淋巴结廓清术 结肠肿瘤 直肠肿瘤 

分 类 号：R735.37[医药卫生—肿瘤]