进展期胃癌术中行热蒸馏水灌洗加氟尿嘧啶腹腔化疗的临床观察  被引量:7

Advanced gastric cancer: warm distilled water plus 5-fluorouracii intraperitoneal chemotherapy during operation

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作  者:左世东[1] 廖恒祥[1] 

机构地区:[1]湖北省中医院普外科,武汉430061

出  处:《腹部外科》2012年第2期106-107,共2页Journal of Abdominal Surgery

摘  要:目的评价术中热蒸馏水加氟尿嘧啶(5-FU)灌注化疗进展期胃癌的疗效。方法对2004年1月至2006年12月期间进展期胃癌27例在术中先以热蒸馏水3000ml灌洗腹腔、吸尽冲洗液后再用生理盐水200ml加5-FU1000mg灌入腹腔并保留,观察术后腹腔引流液脱落细胞及化疗毒副反应。结果病人术后除胃肠道功能恢复时间略延长并轻度骨髓抑制外,无其它不良后果,均痊愈出院,随访5年生存率为44.4%。结论进展期胃癌根治术中行腹腔热蒸馏水灌洗加5-FU灌注化疗安全可行,有杀灭腹腔内残余微小癌和脱落癌细胞的作用,能改善预后。Objective To evaluate the efficacy of intraoperative warm distilled water plus 5-fluorouraeil (5-FU) perfusion chemotherapy for advanced gastric cancer. Methods During Jan. 2004 to Dec. 2006,27 patients with advanced gastric carcinoma were subjected to intraperitoneal lavage of 3000 rnL warm distilled, the flushing fluid was extracted, and 200 ml normal saline plus 1000 mg 5-FU were perfused intraperitoneally. Exfoliative cells and toxic reaction of chemotherapy were observed. Results Except the slightly delayed recovery time of postoperative gastrointestinal function and mild bone marrow suppression, no other adverse reaction occurred, and all patients were cured. During a follow-up period,the 5-year survival rate was 44. 4 %. Conclusion Intraperitoneal warm distilled water plus 5- FU perfusion chemotherapy in radical gastrectomy for advanced gastric cancer is feasible and safe, and may kill the intraperitoneal residual occult carcinoma and exfoliated cancer cells.

关 键 词:胃肿瘤 氟尿嘧啶 化学疗法 肿瘤 局部灌注 

分 类 号:R735.2[医药卫生—肿瘤]

 

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