血红素铁的肠铁吸收及调控机制研究进展  

Intestinal Absorption of Heme Iron and Its Regulation Mechanism

作　　者：耿丽娜[1,2] 李亚永[3] 于鹏[2] 常彦忠[2] 段相林[2] 

机构地区：[1]河北师范大学化学与材料科学学院,石家庄050016 [2]河北师范大学生命科学学院铁代谢分子生物学研究室,石家庄050016 [3]石家庄市第九医院内科,石家庄050000

出　　处：《中国科学：生命科学》2012年第4期269-276,共8页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:30870265);中国博士后科学基金(批准号:20070410866);河北省自然科学基金(批准号:C2010000410);河北省自然科学青年基金(批准号:B2010000378);河北师范大学博士基金(批准号:L2006B18);河北师范大学青年基金(批准号:L2009Q09)资助项目

摘　　要：肠铁吸收及调节机制是机体维持铁稳态的关键环节.对非血红素铁的吸收及调控机制研究较多,而对血红素铁的报道较少,对其吸收及调控机制还需深入研究.本文依据最新的研究进展,介绍了血红素铁的肠铁吸收途径及其调控机制,希望对预防和治疗铁代谢相关疾病提供基础资料.Intestinal iron absorption and its regulation are the key step in iron homeostasis. A large number of reports are involved in the absorption and regulation mechanism of non-heme iron; however, those of heme iron are much less, which still remains to be elucidated. Thus, the study of heme iron absorption and regulation has received much attention in recent years. This review summarizes the possible pathways and molecular mechanisms of heme intake by small intestine and its regulation according to the latest research progress. It will facilitate the understanding of iron absorption especially heme iron and regulation mechanism by intestine, which is important to prevention and treatment of iron metabolism disorders and iron-related diseases.

关 键 词：血红素铁 铁摄取 铁转运 铁代谢 

分 类 号：R341[医药卫生—基础医学]