MicroRNA的研究进展及其与肺癌的关系  

Research Progress of MicroRNA and Its Relationship with Lung Cancer

作　　者：姜波[1] 王玉明[1] 段勇[1] 

机构地区：[1]昆明医学院第一附属医院检验科,昆明650032

出　　处：《现代检验医学杂志》2012年第1期5-9,共5页Journal of Modern Laboratory Medicine

摘　　要：microRNA是一类长约19-25个核苷酸的非编码小分子RNA，通过与靶mRNA的3＇UTR结合，抑制mRNA翻译或增加其稳定性而发挥作用。肺癌是目前全世界病死率最高的癌症之一，虽然对肺癌的研究取得了一定的进展，但是5年生存率并没有得到明显改善。miRNA与肺癌的发生、发展关系密切，可能在肺癌的诊断、治疗及预后监测中发挥重要作用。MicroRNAs are a new class of small, non-proteincoding RNAs of 19-25nt in length,They are thought to repress the translation of mRNA or increasing the instability of mRNA by hybridizing to complementary sequences in 3 ＇UTR （3＇ untranslated region） of target messenger RNA （mRNA）. Lung cancer is the leading cause of cancer mortality worldwide, though a few progress has been made in the research of lung cancer,The 5-year survival rate has only been marginally im- proved in the last two decades despite the development of new therapeutic agents and improved patient care. MiRNAs are closely related to lung cancer and play an important part in the diagnosis, therapy,surveillance and prognosis of lung cancer.

关 键 词：MICRORNA 肺癌 

分 类 号：R734.2[医药卫生—肿瘤] Q522[医药卫生—临床医学]