LL-37抗菌肽及其与牙周病的关系  

Antimicrobial peptide LL-37 and its relationship between periodontal disease

作　　者：苏瑞英[1,2] 陈珊珊[1,2] 赵蕾[2] 

机构地区：[1]口腔疾病研究国家重点实验室四川大学 [2]四川大学华西口腔医院牙周科,成都610041

出　　处：《国际口腔医学杂志》2012年第3期324-327,共4页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(30471890);高等学校博士学科点专项科研基金新教师基金资助项目(200806101107)

摘　　要：牙周病是一种微生物感染导致的牙周组织炎症破坏性疾病,先天性免疫防御功能正常与否与牙周炎的发展转归息息相关。组织蛋白酶抑制素cathelicidin是一种内源性抗菌肽,人源阳离子抗菌肽(hCAP)-18和LL-37是迄今发现的唯一的cathelicidin家族成员,而前者是其前体形式,后者则是其有活性的成熟形式。本文就hCAP-18和LL-37,LL-37的功能,LL-37与牙周病的关系等研究进展作一综述。Periodontal disease is a chronic inflammatory disease that leads to destruction of the periodontium.The abnormal innate immune defense and outcome of periodontal disease is closely related.Cathelicidin is one of endogenous peptide,hCAP-18 and LL-37 is the only member of the cathelicidin family known to exist in human.The former is regarded as an inactive precursor,and the latter is the active mature form.In this review,we emphasize on the hCAP-18,the function of LL-37 and its relationship between periodontal disease.

关 键 词：LL-37 抗菌肽 组织蛋白酶抑制素 牙周病 先天免疫 

分 类 号：R781.4[医药卫生—口腔医学]