P_2Y受体与三叉神经痛之间的关系  

The relationship between trigeminal neuralgia and P_2Y receptors

作　　者：赵莉莉[1] 孙晖[1] 王元银[1] 王烈成[2] 

机构地区：[1]安徽医科大学口腔医院口腔颌面外科,合肥230032 [2]安徽医科大学口腔医院基础医学院生理学教研室,合肥230032

出　　处：《国际口腔医学杂志》2012年第3期336-338,共3页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(30670694);安徽省自然科学基金资助项目(11040606M204)

摘　　要：腺苷三磷酸(ATP)作为一种重要的神经递质具有广泛的生物学效应。多种伤害性刺激均可引起三叉神经节(TG)神经元释放ATP,ATP激活P2受体可引起疼痛。P2受体又分为P2X和P2Y两类。在受损的TG神经元上,P2Y受体的表达明显增多。本文就ATP与P2Y受体表达间的相关性、P2Y受体在TG中的信号转导机制、P2Y受体对神经损伤性痛觉信号的转导作用等研究进展作一综述。As an important neurotransmitter,adenosine triphosphate（ATP） has a wide range of biological effects.A variety of noxious stimulation can cause trigeminal ganglion neurons releasing ATP,and ATP can induce pain through activation of P2 receptors.P2 receptors can be divided into P2X and P2Y receptors.And P2Y receptors expression significantly increased in impaired trigeminal ganglion neurons.In here,the research progress of the relevance of ATP and the expression of P2Y receptor,the signal transduction mechanisms of P2Y receptor which in TG,and the transduction of P2Y receptor on nerve injury pain signal were reviewed.

关 键 词：腺苷三磷酸 P2Y受体 G-蛋白偶联受体 三叉神经痛 

分 类 号：R745.1[医药卫生—神经病学与精神病学]