胰岛素样生长因子-Ⅰ及其与髁突软骨发育的调控  

Insulin-like growth factor-Ⅰ and its regulation on the development of mandibular condylar cartilage

作　　者：江莉婷[1] 高益鸣[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院口腔科,上海200025

出　　处：《国际口腔医学杂志》2012年第3期360-364,共5页International Journal of Stomatology

基　　金：上海市科委医学引导基金资助项目(114119a3500)

摘　　要：出生后的髁突软骨处于复杂的力学微环境中,其生长改建的生物学基础是髁突软骨细胞的增殖和分化。胰岛素样生长因子(IGF)-Ⅰ是髁突软骨生长发育过程中重要的生长因子之一。在细胞学水平,IGF-Ⅰ受胰岛素样生长因子连接蛋白(IGFBP)调控,通过与其受体的结合、激活来发挥生物学效应,其中包括调控细胞增殖、分化及程序性死亡,加快髁突软骨基质合成,参与髁突软骨细胞内力学信号的转导等。本文就IGF-Ⅰ及其受体,IGFBP及IGF-Ⅰ调控髁突软骨发育及其机制的研究作一综述。The postnatal condylar cartilage lives in complex mechanical micro-circumstances,and its growth and modification depends on proliferation and differentiation of condylar chondrocytes.Insulin-like growth factor（IGF）-Ⅰ is one of the important growth factors during growth and development in the condylar cartilage.At the cellular level,IGF-Ⅰexerts its biological actions through the binding and activation of IGF-Ⅰ,and its bioefficacy is modulated by IGF binding proteins（IGFBP）.IGF-Ⅰ induces variety cellular responses,including cell proliferation,differentiation,and aopotosis,promoting matrix synthesis and taking part in intercellular signal mechanotransduction.The article reviews IGF-Ⅰ and its receptor,IGFBP and its role and mechanism on the development of postnatal mandibular condylar cartilage.

关 键 词：胰岛素样生长因子 髁突软骨 发育 作用机制 

分 类 号：R782.6[医药卫生—口腔医学]