微小RNA与口腔癌前病变  

Micro RNAs and oral premalignant lesions

作　　者：朱晓寒[1] 付纪[1] 陈谦明[1] 曾昕[1] 

机构地区：[1]四川大学华西口腔医院黏膜科,成都610041

出　　处：《国际口腔医学杂志》2012年第3期394-396,400,共4页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(30772424;81072218);四川省青年科技基金资助项目(09ZQ026-037)

摘　　要：微小RNA是非编码单链小分子RNA,通常在转录后水平通过降解抑制目标信使RNA参与基因调控,目前研究发现微小RNA与口腔癌关系密切,在某些口腔癌前疾病的癌变过程中发挥着重要作用,此文就微小RNA与口腔癌前病变的关系作一综述。Micro RNAs are small non-coding RNAs that mediate gene expression at the post-transcriptional level by degrading or repressing target messenger RNAs.The current studies showed micro RNAs were related to many oral cancers and played a key role in the tumorigenesis of some oral premalignant lesions.The relationship of micro RNAs and oral premalignant lesions was reviewed in the article.

关 键 词：微小RNA 口腔癌前病变 口腔肿瘤 

分 类 号：R739.8[医药卫生—肿瘤]