葡萄糖转运蛋白及其与口腔鳞状细胞癌的关系  

Glucose transporters and their relationships with oral squamous cell carcinoma

作　　者：江寰[1] 林志勇[1] 

机构地区：[1]山东大学附属省立医院口腔科,济南250012

出　　处：《国际口腔医学杂志》2012年第3期401-403,407,共4页International Journal of Stomatology

摘　　要：葡萄糖转运蛋白(GLUT)是一组位于哺乳动物细胞膜上的非能量依赖性转运蛋白,是负责将葡萄糖向细胞内转运的主要载体。据报道,GLUT在多种恶性肿瘤组织中表达异常,且其表达与肿瘤的发生、发展及预后密切相关。GLUT有可能为口腔鳞状细胞癌的早期诊断及治疗提供一条新思路。本文就GLUT与口腔鳞状细胞癌的相关性研究进展作一综述。Glucose transporter（GLUT）s are a group of non energy dependent transport proteins in mammalians＇ cell membrane,which are the main carriers responsible for transporting glucose into cells.Abnormal GLUTs＇ expressions have been reported in many human cancers,and the positive staining of GLUTs is closely related to the genesis,development and prognosis of tumor.GLUTs may be used to develop a new method for early diagnosis and treatment of oral squamous cell carcinoma.This article reviews the research progress on relationships of GLUTs and oral squamous cell carcinoma.

关 键 词：葡萄糖转运蛋白 口腔鳞状细胞癌 预后 

分 类 号：R739.8[医药卫生—肿瘤]