糖尿病视网膜病变与糖代谢氧化还原的关系  

Relationship between diabetic retinopathy glucose metabolism and redox imbalance

作　　者：孟宪敏[1] 王光璐[1] 金秀英[1] 

机构地区：[1]北京市眼科研究所,100005

出　　处：《眼科研究》2000年第1期86-88,共3页Chinese Ophthalmic Research

摘　　要：许多研究表明非酶糖化和葡萄糖自身氧化伴随着游离基的产生,是一个糖化氧化过程。多原醇途径使视网膜内还原型烟酰胺腺嘌呤二核苷酸(NADH)和氧化型烟酰胺腺嘌呤二核苷酸(NAD+)比率升高,模拟低氧反应,改变了视网膜内氧化还原平衡。非酶糖化和山梨醇途径引起的氧化还原损伤是糖尿病视网膜病变(DR)发生的主要原因之一。Many studies show that nonenzymatic glycation and glucose autoxidation which are accompanied by generation of free radicals is a process of glycation and oxidation.The polyol pathway increases the retinal ratio of the reduced form of nicotinamide adenine dinucleotide(NADH) and the oxidized form of nicotinamide adenine dinucleotide(NAD +) causing retinal hypoxia like redox imbalance,or “pseudohypoxia”.Oxidative injury caused by nonenzymatic glycation and the polyol pathway is one of major reasons for the occurrence of diabetic retinopathy(DR).

关 键 词：非酶糖化 糖尿病 视网膜病变 糖化氧化 

分 类 号：R771.3[医药卫生—眼科]