食管癌外照射综合高剂量率后装治疗价值的探讨  

Clinical analysis of high dose rate intraluminal after loading irradiation for treatment of esophageal cacinoma

作　　者：刘庆深[1] 林连兴[1] 张小贤[1] 李忆璇[1] 

机构地区：[1]广东省汕头市中心医院放疗科,广东汕头515031

出　　处：《癌症》2000年第2期170-172,共3页Chinese Journal of Cancer

摘　　要：目的 :探讨食管癌外照射加腔内后装治疗的价值及后装治疗合适的每次剂量与总剂量。方法 :1992年 10月至 1993年 5月 112例经病理证实的食管癌患者 ,外照射加腔内照射 5 2例 ,单纯外照射 60例 ,分组比较。并将综合组的剂量分组进行生存率的比较。结果 :综合组的 1、3、5年生存率分别为 73 %、3 2 .7%、2 3 % ;对照组的 1、3、5年生存率分别为 4 1.6%、18.3 %、8.3 %。经统计学处理有明显差异。其中病变长度小于或等于 5cm外照射加后装的病例 1、3、5年生存率比单纯外照射明显增高 ,统计学有显著性差异。而长度大于 5cm的病例 ,两组病人差别不大。结论 :外照射综合高剂量率后装治疗对病灶小于或等于 5cm的食管癌可明显提高疗效。掌握后装剂量是提高生存率的关键。外照射 60Gy后再加腔内后装 5Gy/次 ,总量Objective: To analyze the therapeutic effect of high dose rate intraluminal after loading irradiation (ALI) plus extemal irradiation (EI) on patients with esophageal cacinoma (EC),and evaluate optimal total dose of and dosing schedule for ALI. Methods:From October,1992 to May 1993, we total treated of 112 EC cases, in which 52 patients with ALI+EI and 60 cases by EI alone. The survival rate between two groups was compared. Results: The 1 , 3 , 5 year survival rate in ALI+EI group was 73.5%, 32.7%and 23.0%respectively. While in EI group, it was 41.6%, 16.6%and 8.3%, respectively, which was significantly different. For the cases whose lesions were no more than 5cm, had significantly higher 1 ,3 and 5 year survival vate in ALI+EI group than in EI group.However,there was no difference for survival rate between the two groups,if the tumor longer than 5cm. Conclusion: Treatment for EC patient with ALI plus EI could significantly enhence therapeutic efficacy when the lesion not greater than 5cm. The dose is the key factor to improve the prognosis. We conclude that 60Gy of EI plus 15Gy/3 times of ALI might be the optimal dose.

关 键 词：食管肿瘤 高剂量率 腔内后装 放射疗法 

分 类 号：R735.1[医药卫生—肿瘤]