CYP2E1与非酒精性脂肪肝  

CYP2E1 and nonalcoholie fatty liver disease

作　　者：王悦之[1] 张玉[1] 

机构地区：[1]复旦大学附属华山医院老年科,上海200040

出　　处：《胃肠病学和肝病学杂志》2012年第4期384-386,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：非酒精性脂肪性肝病(nonalcoholie fatty liver disease,NAFLD)是一种最常见的肝脏疾病,它的高发病率越来越受到广泛重视。细胞色素氧化酶P450-2E1亚型(CYP2E1)是参与氧化应激和脂质过氧化过程中的关键酶。"二次打击"学说为医学界普遍接受的非酒精性脂肪肝的发病机制。在非酒精性脂肪肝的"二次打击学说"中,CYP2E1介导的脂质过氧化亦发挥重要的作用。通过对CYP2E1介导的脂质过氧化在脂肪性肝病发病机制中作用的进一步深入研究,有可能探索出有效治疗脂肪性肝病的新途径。Nonalcoholie fatty liver disease is one of the most common liver diseases.More and more importance has been attached to the high incidence of NAFLD.A key hepatic enzyme producing oxidative stress and lipid peroxidation is cytochrome P-450 2E1（CYP2E1）.The mechanism of nonalcoholic fatty liver remains most investigators accept to the second-hit theory.Lipid peroxidation induced by CYP2E1 also plays a vital role refered to the second-hit theory of nonalcoholic fatty liver.With advanced investigation of the impact of lipid peroxidation induced by CYP2E1 on the mechanism of fatty liver disease,it is likely to explore novel method to treat fatty liver disease effectively.

关 键 词：非酒精性脂肪肝 CYP2E1 氧化应激 “二次打击”学说 发病机制 

分 类 号：R575.5[医药卫生—消化系统]