肝细胞癌中ATP7B的表达及意义  

Expression and significance of ATP7B in hepatocellular carcinoma

作　　者：林哲绚[1] 韩溟[2] 

机构地区：[1]汕头大学医学院分析测试实验室,广东汕头515041 [2]汕头大学医学院第二附属医院急诊科,广东汕头515041

出　　处：《临床肝胆病杂志》2012年第4期273-275,共3页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81172088)

摘　　要：目的检测肝细胞癌组织ATP7B蛋白的表达,探讨其临床及病理学意义。方法采用SP免疫组织化学方法检测ATP7B在9例正常肝组织及41例肝癌组织中的表达,分析其表达水平与临床病理特征的关系。结果 ATP7B在肝癌组中的阳性表达率为73.2%,显著高于正常肝组织(33.3%)(P<0.05)。增高的ATP7B表达与癌细胞分化程度显著相关(P<0.05),高中低分化癌组织阳性表达率分别为62.5%、66.7%及92.3%。但其阳性表达率与TMN临床分期或肿瘤是否有血管浸润无关(P>0.05)。结论肝细胞癌组织ATP7B阳性表达率显著升高,且与肿瘤分化程度有关,这对临床病理分级具有一定参考价值。Objective To determine the expression of copper-transporting P-type Adenosine Triphosphatase（ATP7B） in hepatocelluar carcinoma tissue and explore its clinical and pathological significance.Methods Immunohistochemical method was used to determine the expression of ATP7B in 41 hepatocellular carcinoma tissue samples and 9 normal hepatic tissues.Then the relationship between ATP7B expression and clinic-pathologic features were analyzed.Results The expression of ATP7B in hepatocellular carcinoma tissue increased significantly than those in normal hepatic tissue（P0.05）,the positive expression rates were 73.2% in carcimoma tissue and 33.3% in normal tissue,respectively.In addition,the increasing expression of ATP7B was significantly correlated with differentiation of malignancy（P0.05）,the positive expression rates were 62.5% in mildly differentiated tissue,66.7% in moderately differentiated tissue and 92.3% in poorly differentiated tissue.However,there was no significant correlation between ATP7B expression and TMN staging or vascular invasion（P0.05）.Conclusion Increased expression of ATP7B was shown in hepatocellular carcinoma and related to tumor differentiation degree,which made it valuable for pathological diagnosis.

关 键 词：癌 肝细胞 腺苷三磷酸酶类 

分 类 号：R735.7[医药卫生—肿瘤]