实验性咬合功能减退及功能恢复对大鼠下颌骨骨矿密度的影响  

Effect of experimental occlusal hypofunction and its recovery on mandibular bone mineral density in rats

作　　者：周国锋[1] 项立新[1] 黎红[2] 李小凤[2] 

机构地区：[1]浙江医院口腔科,浙江杭州310013 [2]浙江中医药大学附属杭州口腔医院特需科,浙江杭州310014

出　　处：《上海口腔医学》2012年第2期134-138,共5页Shanghai Journal of Stomatology

基　　金：四川省科技厅支撑项目(2009FZ0065)~~

摘　　要：目的:探讨实验性咬合功能减退及咬合功能恢复对大鼠下颌骨骨矿密度的影响。方法:60只雄性SD大鼠,随机等分为咬合功能减退组、咬合功能恢复组和空白对照组。于实验开始时(0周)和第2、4、6、8周麻醉下处死动物,测量大鼠体重,并用Micro-CT测量下颌第一磨牙区域松质骨和皮质骨的骨矿密度(BMD)。采用SPSS12.0软件包对数据进行统计学处理。结果:与对照组相比,咬合功能减退组大鼠根分叉区和根尖区松质骨BMD于实验4周后降低(P<0.05),颊、舌侧松质骨BMD于实验6周后开始降低(P<0.01),且均持续到实验结束(P<0.01);咬合功能恢复组大鼠在第8周时除根分叉区外(P<0.05),根尖区及颊、舌位点松质骨BMD恢复至正常水平,高于咬合功能减退组(P<0.01);在第6周和第8周时,咬合功能减退组大鼠舌侧中部和基底区皮质骨BMD较对照组降低(P<0.05),而咬合功能减退组大鼠颊侧以及咬合功能恢复组大鼠颊、舌侧皮质BMD与对照组无显著差异。结论:咬合功能减退可导致大鼠下颌骨松质骨和皮质骨BMD的降低,咬合功能恢复可逆转下颌骨骨矿密度的减少。PURPOSE： To examine the effect of experimental occlusal hypofunction and recovery on mandibular bone mineral density（BMD）.METHODS： Sixty Sprague-Dawley（SD） male rats were randomly divided into experimental occlusal hypofunction group,experimental occlusal recovery group and control group,with 20 rats in each group.They were killed under deep anaesthesia at 0-,2-,4-,6-,and 8-week,after that the mandibles were immediately removed for measuring the BMD of cancellous and cortical bone in the first molar region with micro-CT.SPSS12.0 software package was used for statistical analysis.RESULTS： At 4-week,the cancellous bone density at the bifurcation of the root and the root apex decreased in the hypofunction group（P〈0.05）,whereas the cancellous bone density on the buccal and lingual sides became lower at 6-week compared with the control group（P〈0.01）,and they all lasted until the end of the experiment（P〈0.01）.In the recovery group,the density on the buccal side,lingual side and at the root apex except for the bifurcation of the root had recovered to normal level compared with the control group at 8-week.At 6-and 8-week,cortical bone density in the hypofunction group had reduced in the lingual middle and lingual basal cortical bone areas（P〈0.05）.However,there was no difference between the buccal side in hypofunction group and control group at all the time-points.The same results were observed between the buccal and lingual sides in the recovery group compared with control group.CONCLUSIONS： Experimental occlusal hypofunction could result in the decrease of BMD in both cancellous and cortical bone in rats.Recovery of occlusal hypofunction may restore decreased BMD in mandible.

关 键 词：咬合 下颌骨 骨矿密度 

分 类 号：R783[医药卫生—口腔医学]