甲胎蛋白在失代偿期肝硬化肝组织再生中的作用  

The role of AFP playing in the regeneration of decompensated hepatocirrhosis tissue

作　　者：杨列永[1] 李苓[1] 鲁荣华[1] 原彤彤[1] 杨群[1] 

机构地区：[1]滕州市中心人民医院,山东滕州277500

出　　处：《求医问药（下半月刊）》2012年第3期585-585,587,共2页Seek Medical and Ask The Medicine

摘　　要：[目的]观察失代偿期肝硬化患者肝脏功能的恢复与治疗前甲胎蛋白水平之间的关系,了解甲胎蛋白与肝脏再生的相关性。[方法]36例诊断为慢性乙型肝炎、肝炎肝硬化(失代偿期)的病人按甲胎蛋白的高低分为低AFP组和高AFP组。应用拉米夫定抗病毒治疗,观察0、1、2、4、6月白蛋白、凝血酶原活动度的变化。分析AFP的高低对肝功能恢复的影响。[结果]6个月后,代表肝脏合成功能的白蛋白和凝血酶原活动度有明显变化,高AFP组的白蛋白和凝血酶原活动度升高的程度明显大于低AFP组,两组差异有显著性(P<0.05);白蛋白和凝血酶原活动度升高的程度与AFP的高低有密切相关性。[结论]甲胎蛋白是影响肝脏功能恢复的因素之一,AFP可以作为预测失代偿期肝硬化预后的指标之一,可能是肝脏生长的重要调节因子。[Objective]To observe the relationship between AFP before treatment and liver function recovery in liver cirrhosis patients,and discuss the correlationship between AFP and liver regenation.[Method]36 patients of liver cirrhosis of HBV are divided into low AFP group and high AFP group according to the AFP level,and observe the changes of Albumin and Prothrombin activity before and after 1.2.4. 6 months treatment of Lamivudine,to analyze the role of AFP played in the recovery of liver function.[Results]A great change is observed in the Albumin level and Prothrombin activity after 6 months treatment.The high AFP group presents a higher increasment in Albumin level and Prothrombin activity,and the difference is significant.There is a close correlation between AFP and the increasment of Albumin and Prothrombin activity.[Conclusion]AFP is one functional factor in the recovery of liver function and progsis in liver cirrhosis patients,and may be a regulated factor in liver growth.

关 键 词：肝硬化 失代偿期肝硬化 甲胎蛋白 肝脏再生 相关性 

分 类 号：R575.2[医药卫生—消化系统]