肝癌组织膜联蛋白A2异常表达及临床病理特征分析  

Abnormal expression of Annexin A2 and its clinicopathologic characteristics in tissues of hepatocellular carcinoma

作　　者：张海健[1] 秦呈林[1] 姚宁华[1] 蔚丹丹[1] 严晓娣[1] 陈洁[1] 姚登福[1] 

机构地区：[1]南通大学附属医院临床医学研究中心,南通226001

出　　处：《南通大学学报（医学版）》2012年第2期110-113,F0003,共5页Journal of Nantong University(Medical sciences)

基　　金：江苏省高等教育机构优势学科建设(PAPD);南通市社会发展项目(HS2011012)

摘　　要：目的:分析肝细胞性肝癌(HCC)组织中膜联蛋白A2(ANXA2)的异常表达及其临床病理学特征。方法:以自身配对法分别收集30例HCC患者经手术切除后的癌灶、癌旁和远癌组织,用免疫组化方法检测组织中ANXA2的表达,分析ANXA2表达的临床病理特征。结果:HCC的癌灶组织中ANXA2定位于细胞的胞膜和胞浆;癌旁组织中ANXA2主要定位于胞浆,而远癌组织中未见ANXA2明显表达。癌灶组织中ANXA2表达强度明显高于癌旁(Z=6.113,P<0.01)和远癌组织(Z=7.328,P<0.01),并且其表达水平与HBV感染和门静脉癌栓有关,而与患者年龄、性别、肿瘤大小、AFP浓度、肿瘤数目和分化程度间差异无统计学意义。结论:HCC组织中ANXA2过表达与HCC的进展有关,是肝癌诊断的有用分子标志物之一。Objective： To investigate the distribution and expression level of Annexin A2（ANXA2） and its clinicopathologic characteristics in tissues of hepatocellular carcinoma（HCC）.Methods： HCC,the self-controlled adjacent-,and distant-cancerous tissues were collected from 30 HCC patients.The expression of ANXA2 in these specimens was detected by immunohistochemistry.Results： Positive ANXA2 staining was localized in both cell membrane and cytoplasm in HCC,and only in cytoplasm in their self-controlled adjacent tissue.No positive staining was found in their distant-cancerous tissues.The intensity of ANXA2 expression was significantly higher in HCC tissues more than that in the self-controlled adjacent（Z=6.113,P0.01） or distant-cancerous tissues（Z=7.328,P0.01）,correlated with HBV infection and portal vein thrombus,but not with patients＇age,sex,tumor size,AFP level,number of tumor,and differentiation degree.Conclusion： Abnormal expression of hepatic ANXA2 was closely associated with the progression of HCC,and its detection could be a useful molecular marker for HCC diagnosis.

关 键 词：肝细胞性肝癌 膜联蛋白A2 免疫组化 临床病理学特征 

分 类 号：R735.7[医药卫生—肿瘤]