环氧化酶-2和血管内皮生长因子在鼻咽癌组织中的表达及相关性  

Expression and correlation of cyclooxygenase-2 and vascular endothelial growth factor in nasopharyngeal carcinoma

作　　者：白薇琦[1] 胡宝华[1] 汤建国[2] 李旋[2] 黄蓉[3] 俞吉霞[3] 顾利萍[3] 

机构地区：[1]宁波市第二医院耳鼻咽喉科,浙江宁波315000 [2]浙江大学医学院附属邵逸夫医院耳鼻咽喉-头颈外科 [3]宁波市第二医院病理科

出　　处：《临床耳鼻咽喉头颈外科杂志》2012年第9期408-410,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：宁波市科技局立项课题(No:2010C50029)

摘　　要：目的:探讨环氧化酶-2(COX-2)、血管内皮生长因子(VEGF)在鼻咽癌组织中的表达及其相关性。方法:用免疫组织化学SP法检测58例鼻咽癌患者(鼻咽癌组)和38例鼻咽炎症患者(对照组)黏膜组织中COX-2、VEGF的表达。结果:COX-2、VEGF在鼻咽癌组中的表达均明显高于对照组(均P<0.05)。COX-2、VEGF的表达与鼻咽癌TNM分期有关,Ⅲ～Ⅳ期明显高于Ⅰ～Ⅱ期(P<0.05);与鼻咽癌的浸润和转移有关,有颈淋巴结转移者的表达率明显高于无颈淋巴结转移者(P<0.05)。鼻咽癌组织中COX-2、VEGF的表达呈正相关(r=0.302,P<0.05)。结论:COX-2、VEGF在鼻咽癌发生、发展中起重要作用,在鼻咽癌淋巴结转移中可能有协同效应。Objective：To evaluate the Expression and correlation of cyclooxygenase-2（COX-2） and vascular endothelial growth factor receptor（VEGF） in nasopharyngeal carcinoma.Method：In this study,expression levels of COX-2,VEGF were examined in 58 patients with nasopharyngeal carcinoma and 38 patients with inflammation in nasopharyngeal mucosa by immunohistochemistry method.Result：The expression of COX-2,VEGF were higher in nasopharyngeal carcinoma than those in nasopharyngeal mucosa（P0.05）,and they had some correlation with the invasion and lymphatic metastasis and with the clinical stage of nasopharyngeal carcinoma（P0.05）.The expression of COX-2 was positively correlated with that of VEGF（P0.05）.Conclusion：Thecoexpression of COX-2 and VEGF may play animportant role in the carcinogenesis and development of nasopharyngeal carcinoma,and they may promote lymph node metastasis of nasopharyngeal carcinoma.

关 键 词：环氧化酶 血管内皮生长因子 鼻咽肿瘤 

分 类 号：R739.6[医药卫生—肿瘤]