小型猪腹壁拉链模型的建立及其在外科教学中的应用研究  

Establishment of Minipig Abdominal Wall Zipper Model and Its Application in Surgical Teaching

作　　者：汤球[1] 刘志学[1] 余琛琳[1] 崔淑芳[1] 

机构地区：[1]第二军医大学实验动物中心,上海200433

出　　处：《实验动物与比较医学》2012年第2期137-141,共5页Laboratory Animal and Comparative Medicine

基　　金：上海市科技发展基金项目（No.08140901400）

摘　　要：目的建立小型猪腹壁拉链模型，并在教学实践中开展应用性试验，研究小型猪在教学中的应用情况，并收集相关的研究数据，为小型猪腹壁拉链模型后期推广应用奠定基础。方法选用健康、幼龄小型猪20只，分为两组，10只为常规手术组作对照，10只用于建立小型猪腹壁拉链模型。以小型猪为实验对象实施外科教学项目一肠吻合术和肠瘘管手术以及术后手术部位恢复情况动态观察实验。记录实验的耗时、麻醉药用量、小型猪的精神状况、饮食情况以及手术后的恢复情况。结果小型猪腹壁拉链模型成熟、稳定，在外科教学中具有较强实用性。在肠吻合手术中实验中，小型猪腹壁拉链模型组的实验耗时，麻药使用量，以及动物的精神状况等均明显优于常规手术组，此外，模型自身的结构特点还可以方便实验人员手术后的动态观察。结论本研究成功的建立了小型猪腹壁拉链模型，该模型外科教学实验中的应用情况较好，为今后相关科研工作的顺利开展提供了一种全新的动物模型。Objective To build a minipig model of abdominal wall zipper, the teaching practice test was carried out to discuss the application of minipig in teaching. And the research data was collected,which lay the foundation for the late period application of minipig model of abdominal wall zipper. Method Twenty healthy, juvenile minipigs were selected and divided randomly into two groups, with 10 as control for conventional surgery, 10 for the model of abdominal wall zipper. The minipigs were undergone intestinal anastomosis and intestinal fistula surgery. The intra and postoperative recovery period was dynamically observed. The time course of the experiments, quantity of anesthetic, minipig＇s mental status and diet consumption were recorded. Result The minipig model of abdominal wall zipper has strong practicality in the surgical teaching because it＇s a mature and stable model, In intestinal anastomosis surgery, the index was better than the group under conventional surgery such as time course of experiments, quantity of anesthetic, minipig＇s mental status and so on. Moreover, structural features of the model can also facilitate the dynamic observation after surgery for the researchers. Conclusion The minipig model of abdominal wall zipper was established successfully. Application of the model in the surgical teaching appeared effectively. It may be provided a brand-new animal model for future related research.

关 键 词：小型猪 腹壁拉链 外科教学 

分 类 号：Q95-4[生物学—动物学] G642[文化科学—高等教育学]