肾移植术后并发尿路上皮癌11例临床诊治分析  

Development of urothelial tumors following renal transplantation of 11 cases report

作　　者：宋文辉[1] 白志杰[1] 姚世杰[1] 刘谦[1] 王海峰[1] 马庆彤[1] 杨世强[1] 马洪顺[1] 

机构地区：[1]天津市第一中心医院泌尿外科,300192

出　　处：《中国综合临床》2012年第5期528-530,共3页Clinical Medicine of China

摘　　要：目的总结肾移植术后受者并发自体尿路上皮肿瘤的诊治体会及原因分析。方法回顾性分析了2006年1月至2011年7月肾移植术后接受至少6个月的免疫抑制治疗受者的病历资料。结果在1042例肾移植受者中，发生尿路上皮癌者为11例，发生率为1．06％，全部病例资料完整，其中9例（81．8％）因血尿就诊，2例（18．2％）因查体发现。其中6例为多器官尿路上皮癌。所有患者均经手术治疗，术后辅以化疗或者放疗。其后随访发现8例生存良好，3例死亡。结论对肾移植后并发血尿症状的患者要高度重视，密切随访，重视术后检查，要高度警惕尿路上皮癌的可能，早期诊断，重视尿道重建造影和输尿管镜检查的作用，积极行根治性手术治疗，减少免疫抑制齐Ⅱ的用量。Objective To analyze the incidence and clinical features of urothelial tumors in renal allograft recipients. Methods A retrospective analysis of 1042 patients received renal allografts who had taken immunosuppression for at least six months between 2006 and 2011 in The First Centre Hospital of Tianjin was performed. Results Eleven cases of uroepithelial tumors were diagnosed in the 1042 cases of renal transplantation （ 1.06% ）, of whom 9 cases were noticed by hematuria（ 81.8 % ） ,2 cases （ 18.2% ） by medical examination. Six patients were diagnosed with multifocal urothelial carcinomas. Surgery was performed on all the patients with renal tumors and followed by chemotherapy or radiotherapy. Conclusion Malignancies in urinary tract after renal transplantation should be bore in mind. Early diagnosis is very important. The treatment options include reducing immunosuppressive agents and removing tumor lesions completely.

关 键 词：肾移植 尿路上皮癌 根治性手术 

分 类 号：R737.1[医药卫生—肿瘤]