白细胞介素32在肺腺癌中的表达及临床意义  

Expression of Interleukin-32 in Lung Adenocarcinoma and Its Clinical Significance

作　　者：曾庆理[1] 周燕斌[1] 蔡兴东[1] 李少丽[1] 黄琬玲[1] 黄丽霞[1] 王琴琴[1] 

机构地区：[1]中山大学附属第一医院呼吸内科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2012年第2期184-189,共6页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(81071931);广东省自然科学基金(S2011010004703);教育部回国人员科研启动基金(2010-609)

摘　　要：【目的】检测人肺腺癌组织中白细胞介素32(IL-32)的表达,并探讨其表达的临床意义。【方法】采用免疫组化(IHC)的方法检测60例肺腺癌患者的肿瘤组织IL-32的表达情况,分析其表达水平与患者临床病理因素及预后的关系。【结果】免疫组化结果显示IL-32在肺腺癌组织中的强阳性率及总阳性率分别为48.3%(29/60)和85%(51/60),IL-32表达水平与患者的临床分期、淋巴结及远处转移呈正相关(P<0.05),生存分析显示IL-32高表达组与低表达组相比,5年生存率显著降低(P<0.01),Cox比例风险回归模型显示,IL-32表达状态是影响肺腺癌患者总体生存期的独立危险因素之一(P<0.01)。【结论】肺腺癌组织中IL-32表达与侵袭转移及预后有关,可能成为判断肺腺癌患者预后的有效分子标志物。【Objective】 The study was aimed at investigating the expression of IL-32 in human lung adenocarcinoma and clarifying its clinical significance.【Methods】 The expression of IL-32 in 60 cases lung adenocarcinoma tissues was examined using immunohistochemistry.Statistical analyses were applied to test the relation between IL-32 expression and clinicopathologic characteristics including prognosis.【Results】 Immunohistochemical analysis revealed that the strong positive rate and the total positive rate of IL-32 expression in lung adenocarcinoma were 48.3%（29/60） and 85%（51/60） respectively.The expression level of IL-32 was positively correlated with the clinical staging（P = 0.004）,lymph node（P = 0.006） and distant metastasis（P = 0.039）.Survival analysis showed that the 5-year survival rate of patients with high IL-32 expression was significantly lower than those in patients with low expression（P 0.01）.The multivariate Cox proportional hazards regression analysis of prognostic factors for overall survival showed that IL-32 expression was an independent prognostic indicator for the patients with lung adenocarcinoma（P = 0.013）.【Conclusions】 IL-32 expression was closely related with invasiveness and metastasis,as well as prognosis,and it might be an useful biomarker for the prediction of prognosis of lung adenocarcinoma.

关 键 词：白细胞介素32 肺腺癌 侵袭 转移 预后 

分 类 号：R734.2[医药卫生—肿瘤]