门脉高压性胃病患者血浆、尿中内皮素浓度变化及意义  

Signification of the level of plasma endothelin and urinary endothelin in patients with portal hypertensive gastropathy

作　　者：周宇[1] 叶文桃[1] 麦海妍[1] 彭雁忠[2] 

机构地区：[1]湛江市广东医学院附属医院消化内科,广东湛江524001 [2]湖北医科大学附属第一医院传染科,湖北武汉430000

出　　处：《临床肝胆病杂志》2000年第1期47-48,共2页Journal of Clinical Hepatology

摘　　要：本文应用放射免疫法测定 40例门脉高压性胃病 (PHG)患者血桨、尿中内皮素 (ET)含量。结果 ,PHG患者血桨ET(PEt)尿ET(UEt)及PEt/UEt显著高于非PHG肝硬化患者和正常人 (P <0 .0 5 ) ,且与食管静脉曲张程度、脾厚和门脉宽度成正比。轻、重度PHG上述三项指标差异均有显著性 (P <0 .0 5 ) ;提示 ,ET参与PHG的形成机制 ,可能主要与ET使门脉压增高有关。Plasma and urinary endothelin were measured by radioimmunoassay in 40 patients with PHG.The results showed the lever of plasma endothelin(P Et),urinary endothelin(U Et) and the rate of P Et/U Et were significantly higher in patients with PHG than in those with cirrhosis and without PHG (or healthy subjects).P Et,U Et and P Et/U Et were clear difference two grade of PHG.Degree of portal hypertension demonstrated a significant positive correlation with P Et,U Et and P Et/U Et in patients with PHG.This data suggest that P Et participate in mechanism of PHG,which is connected with protal hypertension enhanced by P Et.

关 键 词：胃病 内皮素 门脉高压症 血浆 尿 

分 类 号：R573.9[医药卫生—消化系统]