硫普罗宁治疗酒精性脂肪肝的临床疗效及安全性分析  

The clinical efficacy and safety analysis of tiopronin treatment of alcoholic fatty liver

作　　者：文健[1] 吴永彬[2] 徐晓平[3] 魏威[1] 

机构地区：[1]南方医科大学生物技术学院生物制药系,广东广州510515 [2]南方医科大学基因工程研究所 [3]南方医科大学南方医院消化内科

出　　处：《现代预防医学》2012年第9期2162-2163,2170,共3页Modern Preventive Medicine

摘　　要：目的评价硫普罗宁治疗酒精性脂肪肝的临床疗效。方法将某院收治的酒精性脂肪肝患者68例随机分为研究组和对照组,每组34例,两组患者均给予常规保肝治疗,包括甘利欣注射液250ml静脉滴注qd,4周,门冬氨酸钾镁20ml静脉滴注qd,4周;治疗组患者加用硫普罗宁200mg,3次/d,应用3个月,对照组服用安慰剂治疗。评价两组患者治疗前后AST、ALT、GGT变化及治疗效果。结果治疗后两组患者AST、ALT、GGT水平均较治疗前显著下降,(P﹤0.05),但治疗组下降水平较对照组更明显,两组数据比较差异有统计学意义(P﹤0.05);研究组治疗总有效率为91.2%(31/34),对照组治疗总有效率为64.7%(22/34)(P﹤0.01)。结论硫普罗宁治疗酒精性脂肪肝能显著改善患者肝功能,且无明显不良反应,值得临床推广应用。OBJECTIVE To evaluate the clinical efficacy of tiopronin treatment of alcoholic fatty liver.METHODS 68 patients of alcoholic fatty liver were randomly divided into the study group and the control group,34 patients in each group.The control group was given conventional liver treatment,including intravenous injection with 250ml Ganlixin qd,for 4 weeks,and intravenous infusion of potassium-magnesium aspartate 20ml qd,for 4 weeks,and placebo for 3 months;and the treatment group were given conventional liver treatment and tiopronin 200mg,3 times/d,for 3 months.AST,ALT,GGT changes were evaluated before and after treatment.RESULTS After treatment,AST,ALT,GGT levels decreased significantly compared with before treatment（P﹤0.05）,but the level of the treatment group decreased more significantly than the control group（P﹤0.05）;Total effective rate was 91.2% in the study group（31/34）,and 64.7%（22/34）in the control group was（P﹤0.01）.CONCLUSION Tiopronin is worthy of clinical application to treat alcoholic fatty liver because it can significantly improve liver function and has no significant adverse reactions.

关 键 词：硫普罗宁 酒精性脂肪肝 肝功能 疗效评价 

分 类 号：R575.5[医药卫生—消化系统]