武汉地区健康婴幼儿肺炎链球菌携带率及血清型分布  

Study on the carrying rate and serotype distribution of streptococcus pneumoniae of healthy infants in Wuhan

作　　者：赵德峰[1] 胡权[1] 熊燕[1] 全永霞[2] 艾运生[3] 王建坤 

机构地区：[1]武汉市疾病预防控制中心,武汉480015 [2]武汉市武昌区疾病预防控制中心 [3]武汉市汉阳区疾病预防控制中心 [4]武汉市硚口区疾病预防控制中心

出　　处：《现代预防医学》2012年第9期2166-2168,共3页Modern Preventive Medicine

基　　金：湖北省武汉市卫生局公共卫生科研项目(WG10C01)

摘　　要：目的了解武汉地区健康婴幼儿鼻咽部肺炎链球菌携带率及血清型分布。方法选取武汉地区3个社区,于2009年4月和12月对12～18月龄健康婴幼儿进行鼻咽拭子采样,采用"Optochin"实验进行细菌鉴定,采用"Neufeld反应"试验进行血清分型。结果研究期间共采集596名研究对象鼻咽拭子样本,分离到肺炎链球菌75株,健康婴幼儿鼻咽部肺炎链球菌携带率为12.6%,季节、性别之间携带率差异无统计学意义;血清分型涉及13个型/群,主要分布在19F(20.0%、15/75)、19A(8.0%、6/75)、6A(8.0%、6/75)、15(8.0%、6/75)、6B(6.7%、5/75)、23F(6.7%、5/75)、14(5.3%、4/75),冬季比春季分布广;7价、13价肺炎疫苗的血清覆盖率为38.7%和54.7%。结论武汉地区12～18月龄健康婴幼儿鼻咽部肺炎链球菌携带率低于2岁以上儿童,主要流行血清型以19F为主。OBJECTIVE To study the carrying rate and serotype distribution of nasopharyngeal streptococcus pneumonia of health infants in Wuhan.METHODS the Samples of rhinal and throat from 12-18 month-old healthy infants were collected,who came from 3 communities in Wuhan,at April and December in 2009.We used＂Optoehin＂experiment for strains identification and＂Neufeld reaction＂to test serotype.RESULTS 607 subjects were collected from the samples during the study.75 strains of Streptococcus pneumoniae were isolated,and the rate of healthy infants carrying streptococcus pneumoniae in nasopharynx was 12.4%.The carrying rate of different seasons and sexes had no significant difference;Serotypes involved 13 types/groups,which mainly owned 19F（20.0%,15/75）,19A（8.0%,6/75）,6A（8.0%,6/75）,6B（6.7%,5/75）,15（8.0%,6/75）,23F（6.7%,5/75）,14（5.3%,4/75）,and distributed more widely in winter than in spring;7 and 13-valent pneumococcal vaccine coverage was 38.7% and 54.7% in serum.CONCLUSION The carrying rate of Streptococcus pneumoniae at nasopharyngeal in 12-18 month-old healthy infants is less than that of the children over 2 year-old,and the 19F is the predominant serotype.

关 键 词：健康婴幼儿 肺炎链球菌 携带率 血清分型 

分 类 号：R378.14[医药卫生—病原生物学]