TAFI基因启动子区-2345 2G/1G多态性与脑梗死的关系  

Association between promoter polymorphism-2345 2G/1G of thrombin-activatable fibrinolysis inhibitor gene and cerebral infarction

作　　者：陈煜森[1] 曾志良[1,2] 林智君[1] 冼文川[1] 钟望涛[1] 赵斌[1] 许志恩[1] 

机构地区：[1]广东医学院附属医院神经内科,湛江524001 [2]广东东莞市太平人民医院,东莞523900

出　　处：《中国实用神经疾病杂志》2012年第7期1-3,共3页Chinese Journal of Practical Nervous Diseases

基　　金：2005年教育部留学回国人员科研启动基金;教外司留[2005]546号1

摘　　要：目的分析中国汉族人群TAFI基因启动子区-2345 2G/1G与动脉粥样硬化性脑梗死发病的关系。方法选择225例脑梗死(病例组)和184例健康体检者(对照组)为对象,应用等位基因特导性聚合酶链反应分析方法(AS-PCR)检测-2345 2G/1G多态性。结果 TAFI-2345 2G/1G在病例组的1G等位基因频率为42.9%,对照组为50.8%,2组间差异有统计学意义(P=0.024);病例组1G/1G基因型频率为15.1%,对照组为24.5%,2组间差异有统计学意义(P=0.017)。经Logis-tic回归分析,TAFI-2345 1G/1G基因型与脑梗死的发病有独立相关性。结论 TAFI-2345 2G/1G多态性与动脉粥样硬化性脑梗死的发病有关联,1G/1G基因型可能使脑梗死患病风险降低。Objective To study the association between promoter polymorphism-2345 2G/1G of thrombin-activatable fibrinolysis inhibitor（TAFI） gene and atherosclerotic cerebral infarction（ACI） in Chinese Han population. Methods TAFI-2345 2G/1G genotypes were identified by allele-specific polymerase chain reaction（AS-PCR） in the study which included 225 ACI patients and 184 healthy controls. Results 1G allele frequency of TAFI-2345 2G/1G polymorphism was 42.9% in CI group,and 50.8% in control group,the difference was significant（P=0.024） between the two groups.The frequency of the 1G/1G genotype was 15.1% in ACI group,and 24.5% in control group,the difference was significant（P=0.017） between the two groups.After adjustment for known cerebral vascular risk factors by Logistic regression analysis,TAFI-2345 1G/1G genotype was independently associated with ACI. Conclusion TAFI-2345 2G/1G polymorphism is associated with ACI,1G/1G genotype maybe decrease the risk of ACI.

关 键 词：凝血酶激活的纤溶抑制物(TAFI) 脑梗死 基因多态性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]