施普善治疗急性脑梗死的磁共振波谱成像评价  

Influence of cerebrolysin on magnetic resonance spectroscopy(MRS) and its efficacy for acute cerebral infarction

作　　者：韩立秀[1] 张振华[1] 张鹏[1] 张子宪[1] 胡屹伟[1] 

机构地区：[1]山东枣庄市立医院干部保健科,枣庄277100

出　　处：《中国实用神经疾病杂志》2012年第6期3-5,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察施普善对急性脑梗死患者磁共振氢质子波谱(H magnetic resonance spectroscopy,MRS)及临床症状、体征改善的影响,评价施普善治疗急性脑梗死的疗效。方法选择发病24h内的急性脑梗死患者40例,随机分为施普善治疗组20例及对照组20例。2组治疗前及治疗2周后行美国国立卫生研究院脑卒中量表评分(NIHSS评分),应用MRS在兴趣区上测量氮-乙酰天冬氨酸(NAA)与肌酸(Cr)比值(NAA/Cr)、胆碱复合物(Cho)与肌酸(Cr)比值(Cho/Cr)及乳酸(Lac)与肌酸(Cr)比值(Lac/Cr),并对治疗前后结果进行统计学分析。结果治疗2周后2组NIHSS评分较治疗前均有所降低,施普善治疗组较对照组下降明显(P<0.05),2组病人NAA/Cr较治疗前升高,但施普善治疗组较对照组升高明显(P<0.05),2组病人CHO/Cr及Lac/Cr均较治疗前降低,但施普善治疗组较对照组降低明显(P<0.05)。结论施普善是一种有效的治疗急性脑梗死的神经保护剂。Objective To observe the influence of cerebrolysin on magnetic resonance spectroscopy（MRS） and improvement of clinical symptoms,and study the efficacy of cerebrolysin in treating patients with acute cerebral infarction.Methods Forty patients with onset of acute cerebral infarction within 24 hours were randomly divided into cerebrolysin treatment group（n=20） and control group（n=20）.National institute of health stroke scale（NIHSS） and application in interest on MRS area measurement N-acetylaspartate（NAA） and creatine（Cr） ratio（NAA/Cr）,choline complex（Cho） and creatine（Cr） ratio（Cho/Cr） and lactic acid（Lac） and creatine（Cr） ratio（Lac/Cr）were compared between the two groups.Results There were significant differences in NIHSS between cerebrolysin treatment group and control group after 2 weeks.The improvement in cerebrolysin treatment group was more significant than that of control group（P0.05）.NAA/Cr was higher in cerebrolysin treatment group than that of control group,the differences were significant（P0.05）.CHO/Cr and Lac/Cr were lower in cerebrolysin treatment group than that of control group,the differences were significant（P0.05）.Conclusion Cerebrolysin is an effective neuroprotective agent in treating acute cerebral infarction.

关 键 词：施普善 急性脑梗死 磁共振氢质子波谱(MRS) 

分 类 号：R743.33[医药卫生—神经病学与精神病学]