CD105在声门上型喉癌组织中的表达及其临床病理意义  

Significance of CD105 expression in supraglottic laryngeal squamous cell carcinoma

作　　者：何洪江[1] 崔明宇 王丽[1] 程慧[1] 贾深汕[1] 

机构地区：[1]哈尔滨医科大学附属第三医院头颈鼻咽喉外科,哈尔滨150081 [2]大庆市油田总院

出　　处：《实用肿瘤学杂志》2012年第2期114-118,共5页Practical Oncology Journal

基　　金：黑龙江省卫生厅科研课题项目（2006-171）

摘　　要：目的 研究CD105在声门上型喉癌组织中的表达,评价其标记的微血管密度（IMVD）的临床病理意义.方法 应用免疫组化技术检测CD105在40例声门上型喉癌标本及20例正常喉黏膜标本中的表达情况,并计数其标记的微血管密度（IMVD）.结果 40例声门上型喉癌组织中IMVD值（23.45±8.27个/HPF）明显高于正常喉黏膜组织（P＜0.01）,有淋巴结转移组IMVD值（29.72±2.97个/HPF）明显高于无淋巴结转移组（15.10±3.49个/HPF）（P＜0.01）,IMVD值随临床分期增加而明显增加（P＜0.05）,而IMVD值与肿瘤的分化程度以及病人的年龄、性别等因素无明显相关（P＞0.05）.结论 CD105是肿瘤新生血管的标志,其标记的微血管密度与声门上型喉癌的侵袭转移密切相关,可能作为一种新的肿瘤标志物来监控喉鳞状细胞癌的发生、浸润和转移.Objective To study the expression of CD105 in supraglottic laryngeal squamous cell carcinoma and to evaluate the clinical significance of microvessel density （IMVD）. Method Pathologic paraffin - embedded sections and clinical data from 40 patients with primary squmamous cell carcinoma of larynx and 20 normal mucosae were studied through immunohistochemistry. Microvessel density（IMVD） highlighted by CD105 were counted. Result CD105 expression in tumour tissue was significantly higher than normal health mucosa （ P 〈 0.01 ） ;the mean IMVD value of tumours with metastasis was markedly higher than turnouts with nometastasis （P 〈 0.01 ） ;IMVD increased along with elevated clinical stages （P 〈 0.05 ） ;but there was no correlation between IMVD and tumor differentiation（P 〉 0.05）. Conclusion CD105 is a marker of tumour angiogenesis and an independent indicator for predicting invasion and metastasis of supraglottic laryngeal squamous cell carcinoma.

关 键 词：喉鳞癌 肿瘤微血管生成 微血管密度 CD105 

分 类 号：R734.1[医药卫生—肿瘤]