Rab5A与CD44v9在乳腺癌组织中的表达及其相关性  

The expression and correlation of Rab5A and CD44v9 in breast cancer tissues

作　　者：谷新悦[1] 查尼尔 张明[3] 李志高[3] 

机构地区：[1]哈尔滨医科大学附属第三医院结直肠外科,哈尔滨150081 [2]内蒙古自治区人民医院肿瘤外科 [3]哈尔滨医科大学附属第三医院乳腺外科

出　　处：《实用肿瘤学杂志》2012年第2期125-130,共6页Practical Oncology Journal

基　　金：黑龙江省科技厅科技攻关项目（GC07C350）

摘　　要：目的 研究乳腺癌组织中Rab5A与CD44v9蛋白的表达及其相关性.方法 应用免疫组织化学S-P法检测53例术后乳腺癌标本、21例乳腺良性肿瘤标本中Rab5A与CD44v9蛋白的表达情况.结果 Rab5A与CD44v9蛋白在乳腺癌组的表达率显著高于良性肿瘤组（P＜0.05）;Rab5A和CD44v9蛋白在有淋巴结转移的乳腺癌组中的表达率显著高于无淋巴结转移组（P＜0.05）,并且二者的表达水平均与淋巴结状态相关,二者的表达水平增高,则发生淋巴结转移的概率增加（P＜0.05）;Rab5A和CD44v9蛋白的表达程度与乳腺癌TNM分期呈正相关,分期越晚表达越强（P＜0.05）;乳腺癌组织中,Rab5A与CD44v9蛋白的表达呈正相关（P＜0.05）.结论 Rab5A和CD44v9蛋白在乳腺癌的发生发展、侵袭转移中可能起到协同作用.两者联合检测对于早期诊断乳腺癌及判断其预后有重要的临床意义.Objective To evaluate the expression and correlation of Rab5A and CD44v9 in breast cancer tissues. Methods The expression of Rab5A and CD44v9 in 53 cases of breast cancer tissues and 21 cases of benign breast disease tissues was detected by immunohistochemistry S - P method. Results The expressions of Rab5A and CD44v9 were obviously stronger in breast cancer tissues than that in benign breast disease tissues（ P 〈 0.05 ） ; the expression of Rab5A and CD44v9 were obviously stronger in lymph node - positive eases than that in negative cases （ P 〈 0.05 ）, and＂ were correlated with lymph - node status. With the two proteins expressed at higher levels ,the probability of node - positive cases was enhanced（ P 〈 O. 05 ）. Moreover, the expressions of the two proteins were positive correlation to TNM stage （ P 〈 0.05 ）. In addition, the expressions of the two proteins were positive correlation to each other, the higher levels of either protein was expressed at the higher levels of the other（ P 〈 0.05 ）. Conclusions Rab5A and CD44v9 proteins may play a synergetic role in breast cancer gene- sis, growth, invasion and metastasis. It is indicated that the united detection of the two proteins may offer important clinical significance for breast cancer early diagnosis and prognosis.

关 键 词：乳腺癌 转移 RAB5A CD44V9 

分 类 号：R737.9[医药卫生—肿瘤]