CK17、P16及Ki-67在宫颈鳞状上皮不成熟化生和宫颈上皮内瘤变中的意义  

Expression of CK17,P16 and Ki-67 in differential diagnosis of cervical squamous epithelium immature metaplasia and cervical intraepithelial neoplasia

作　　者：张萍 王怀莉 陈龙 

机构地区：[1]宁夏银川市妇幼保健院病理科,宁夏银川750001

出　　处：《宁夏医学杂志》2012年第4期300-302,共3页Ningxia Medical Journal

摘　　要：目的探讨CK17、P16和Ki-67在宫颈鳞状上皮不成熟化生(IM)和宫颈上皮内瘤变(CIN)中的表达和诊断意义。方法采用免疫组化方法对86例宫颈IM、CIN等病变分别检测CK17、P16和Ki-67的表达情况,并对其表达及意义进行分析。结果 20例对照组鳞状上皮CK17均为(-),CK17在宫颈IM中阳性表达率为100%,明显高于CINI和CINII-III组(11.76%和8.70%);P16在CINI组和CINII-III组中的表达率分别为94.1%和100%,明显高于IM组(8%);Ki-67在CINI和CINII-III组中表达率分别为94.10%和100%,明显高于IM组的65.38%。结论 CK17、P16和Ki-67联合应用有助于IM和CIN病变的诊断及鉴别诊断。Objective To study the expression and find diagnostic significance of CK17,P16 and Ki-67 in cervical squamous epithelium immature metaplasia（IM）and cervical intraepithelial neoplasia（CIN）.Methods 86 cases with varied cervical lesion were studied by immunohistochemical method.Results Comparing with the group of squamous epithelium（n=20）,the CK17 was negative,CK17 was positive in the group of cervical immature metaplasia（n=26）with rate of 100%.This rate was significantly higher than that in the groups of CINI（n=17,11.76%）and CINII-III（n=23,8.70%）.P16 expression rate were 94.1% in the CINI group and 100% in the CINII-III group.These rates were higher than that in the IM group（8%）.Ki-67 has expression rate of 94.10% and 100% in the groups of CINI and CINII-III,respectively.Conclusion The combined applications of CK17,P16 and Ki-67 will help with the differential diagnosis of CIN lesion and IM.

关 键 词：宫颈鳞状上皮不成熟化生 宫颈上皮内瘤变 CK17 P16 KI-67 

分 类 号：R737.33[医药卫生—肿瘤]