肥大细胞与乳腺浸润性导管癌淋巴结转移及淋巴管生成的关系探讨  

Study of the relationship between the expression of Mass Cells and lymph node metastases and lymphangiogenesis in invasive ductal carcinoma

作　　者：黎晴 杨梅[2] 曹桂明[2] 

机构地区：[1]广州市荔湾区人民医院病理室,广东广州510370 [2]南华大学附属南华医院病理科,湖南衡阳421000

出　　处：《海南医学》2012年第9期7-9,共3页Hainan Medical Journal

基　　金：湖南省卫生厅项目(编号:B2006-122);衡阳市2007年社会发展科技支撑计划项目(编号:2007KS25)

摘　　要：目的探讨肥大细胞在浸润性导管癌中的表达及其与淋巴结转移及淋巴管生成的关系。方法用免疫组化染色检查肥大细胞在乳腺良性病变和乳腺浸润性导管癌组织中的表达,用D2-40标记淋巴管并计数。结果肥大细胞数量在乳腺良性病变和乳腺浸润性导管癌之间的差异有统计学意义(P<0.01);乳腺浸润性导管癌中的Ⅰ、Ⅱ、Ⅲ级患者的肥大细胞数量差异有统计学意义(P<0.01)。肥大细胞数量与浸润性导管癌有无淋巴结转移之间的差异有统计学意义(P<0.01)。肥大细胞数量与乳腺癌淋巴管数量呈正相关(r=0.18)。结论肥大细胞数量可作为乳腺浸润性导管癌远期预后判断的参考指标。Objective To observe the expression of mass cells in breast invasive ductal carcinoma,and analyze the relationship between mass cells and lymph node metastasis and lymphangiogenesis.Methods Immunohistochemistry （IHC） was used to detect the levels of Mass cells,and D2-40 was used to mark lymphatic vessels.Results The quantity of mass cells showed significant different in benign breast lesions and invasive ductal carcinoma tissues （P 0.01）,and also showed significant difference between the three grades （grade Ⅰ,gradeⅡ,and grade Ⅲ） of invasive ductal carcinoma （P 0.01）;Statistically significant difference was also found in the quantity of the mass cells between invasive ductal carcinoma with lymph node metastasis and that without lymph node metastasis.Conclusion The quantities of the mass cells was positively correlated with lymphangiogenesis and lymph node metastasis,which could be used as the valuable indexes for the diagnosis and long-term prognosis of breast invasive ductal carcinoma.

关 键 词：乳腺癌 组织学分级 肥大细胞 淋巴管计数 预后判断 

分 类 号：R737.9[医药卫生—肿瘤]