FOXC1蛋白在喉鳞状细胞癌中表达及临床意义  

Expression of FOXC1 protein in laryngeal squamous cell carcinoma

作　　者：贺小玲[1] 王斌全[1] 高伟[1] 张春明[1] 张海利[1] 陈钢钢[1] 

机构地区：[1]山西医科大学第一医院耳鼻咽喉-头颈外科,山西太原030001

出　　处：《现代肿瘤医学》2012年第5期930-933,共4页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(项目编号:81172584)

摘　　要：目的:探讨FOXC1蛋白在人喉鳞癌组织中的表达及其与淋巴结转移、分化程度等临床病理参数间的关系。方法:采用免疫组织化学法检测FOXC1蛋白在喉鳞癌(LSCC)及癌旁正常切缘组织中的表达,并结合临床病理学特征进行统计学分析。结果:FOXC1蛋白阳性表达定位于喉鳞癌细胞的胞核或胞浆,其在LSCC组及对照组中的阳性表达率分别为96.8%和27.1%(P<0.05),FOXC1浆表达与颈部淋巴结转移、分化程度及分型关系密切,而与性别、年龄、临床分期等无明显关系;FOXC1核表达与分型相关,与其它临床病理学参数间无明显相关。结论:FOXC1蛋白在喉鳞癌组织中阳性表达率明显高于癌旁正常切缘组织,它可能在喉鳞癌的侵袭、转移过程中发挥重要作用。FOXC1可能成为判定喉癌外科切缘及分子靶向治疗的新靶标。Objective：To study the expression of FOXC1 in laryngeal squamous cell carcinoma（LSCC） and investigate the correlation between the expression of FOXC1 and clinicopathologic factors,such as lymph node metastasis,differentiation of LSCC.Methods：Immunohistochemistry technique was adopted to detect the expression of FOXC1 in carcinoma tissues（LSCC） and squamous epithelium beside carcinoma tissues（control）.The correlation between the expression of FOXC1 and clinicopathologic factors were statistically analyzed.Results：The positively expressed FOXC1 was located in nucleus or cytoplasm of laryngeal squamous cells.The expressions of FOXC1 in LSCC and control were 96.8% and 27.1%（P0.05）.The cytoplasmic expression of FOXC1 protein in laryngeal squamous cell carcinoma had a relationship with differentiation,tumor location and lymph node metastasis,but not with gender,age,smoking and clinical stage of cancer.The nuclear expression of FOXC1 protein in laryngeal squamous cell carcinoma had a relationship with tumor location,but not with other clinicopathologic factors.Conclusion：FOXC1 expression was significantly increased in LSCC than in control group,which may play an important role in the process of invasion and metastasis of LSCC,the detection of FOXC1 may be an important biological factor affecting the prognosis judgement of LSCC.

关 键 词：FOXC1 喉肿瘤 鳞状细胞癌 E-CADHERIN 免疫组织化学 

分 类 号：R739.65[医药卫生—肿瘤]