急性白血病患者BAG-1、Survivin表达及其临床意义  

Significance of BAG-1 and Survivin proteins expression in acute leukemia

作　　者：李章志[1] 万楚成[1] 宋斌[1] 张金金[2] 夏云金[1] 

机构地区：[1]湖北医药学院附属太和医院血液科,湖北十堰442000 [2]湖北医药学院07级临床系,湖北十堰442000

出　　处：《现代肿瘤医学》2012年第5期1019-1021,共3页Journal of Modern Oncology

基　　金：湖北省十堰市科技攻关项目(编号:2006ZD08)

摘　　要：目的:研究凋亡相关蛋白BAG-1、Survivin在急性白血病患者骨髓白血病细胞中的表达及其临床意义。方法:SABC法检测初治急性白血病患者骨髓单个核细胞BAG-1、Survivin蛋白表达水平,并动态检测患者不同治疗阶段BAG-1、Survivin蛋白表达,与非恶性血液病患者比较。结果:初诊急性白血病患者调亡相关蛋白BAG-1、Survivin表达阳性率显著高于对照组,P<0.05,差异有显著性;完全缓解组与未缓解组比较,P<0.05,差异有显著性。结论:BAG-1、Survivin蛋白是影响急性白血病缓解的重要因素;检测BAG-1、Sur-vivin蛋白对预判急性白血病能否缓解有重要临床意义。Objective：To study the expression of BAG-1 and Survivin proteins in bone marrow mononuclear cells of acute leukemia and its clinical significance.Methods： The expression of BAG-1 and Survivin proteins in bone marrow mononuclear cells of fifty cases with initial diagnosis acute leukemia were detected by SABC immunohistochemistry,and the expression of BAG-1 and Survivin proteins at different stages of treatment were analyzed.Results： The expression of BAG-1 and Survivin proteins in initial diagnosis acute leukemia were significantly higher than that of control（P0.05）,the difference was statistically significant;There was a significant difference between complete remission group and non-complete remission group（P0.05）.Conclusion： The expression of BAG-1 and Survivin proteins is an important prognostic factor in acute leukemia.The detection of BAG-1 and Survivin proteins can predict acute leukemia prognosis.

关 键 词：BAG-1 SURVIVIN 急性白血病 免疫细胞化学 调亡 

分 类 号：R733.71[医药卫生—肿瘤]