荧光原位杂交技术在快速产前诊断应用的研究进展  

Progress in the rapid prenatal diagnosis by using of fluorescence in situ hybridization

作　　者：莫耀禧[1] 莫伟英[1] 谭毅[1] 

机构地区：[1]广西壮族自治区人民医院生殖医学与遗传中心,南宁530021

出　　处：《中国临床新医学》2012年第4期374-376,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：随着分子生物学技术和医学遗传学的发展,产前诊断技术向早期、快速、准确、无创伤发展,使越来越多的出生缺陷能够在胚胎发育的较早期诊断出来。荧光原位杂交技术(FISH)是一种为遗传病诊断提供更直观、快速诊断的分子细胞遗传技术,随着DNA技术的发展与染色体特异性探针的出现,FISH技术越来越多应用于生殖医学领域的临床诊断。该文对FISH技术在快速产前诊断中的研究进展作一综述。With fast development in molecular biology and medical genetics, prenatal diagnosis is becoming rapid, sensitive and non-invasive techniques, more and more birth defects has been diagnosed in early stage of embryonic development. With the advent of chromosome-specific probe and development of DNA technique, fluorescence in situ hybridization （FISH） has widely been used in clinical as a molecular diagnostic technology by providing intuitionistic and rapid diagnosis. In the paper, the research progresses of FISH in the rapid prenatal diagnosis are discussed.

关 键 词：荧光原位杂交 快速产前诊断 植入前遗传学诊断 

分 类 号：R714[医药卫生—妇产科学]