喹诺酮类抗菌药中间体四氟邻苯二甲酸的合成  

SYNTHESIS OF TETRAFLUOROPHTHALIC ACID AS AN INTERMEDIATE OF QUINOLONE ANTIBACTERIALS

作　　者：温新民[1] 刘君[1] 王彦[1] 王惠云[1] 张波[1] 孙勤枢[1] 

机构地区：[1]济宁医学院化学教研室

出　　处：《济宁医学院学报》2000年第1期36-37,共2页Journal of Jining Medical University

摘　　要：目的　合成喹诺酮类抗菌药中间体四氟邻苯二甲酸 ,并改进工艺 ,使之适用于工业化生产。方法　以四氯苯酐为原料 ,经酰亚胺化、氟化、水解得四氟邻苯二甲酸。结果　通过工艺改进 ,收率可达 79%。结论　反应条件温和 ,适用于工业化生产。Objective To improve the synthesis of tetrafluorophthalic acid as an intermediate in preparing quinolone antibacterials.Methods This preparation of tetrafluorophthalic acid started from tetrachlorophthalic anhydride and underwent amidation,fluorination and hydrolysis.Result The yield reached 79% with improved technology.Conclusion All steps were carried out in moderate conditions and they were more suitable for manufacture.

关 键 词：四氟邻苯二甲酸 抗菌药 喹诺酮 合成 

分 类 号：TQ463[化学工程—制药化工] R978.19[医药卫生—药品]