兔急性细菌性胆囊炎不同病期病变程度分析  

Analysis of pathological changes in different periods of rabbits with acute bacterial cholecystitis

作　　者：张鼐鹏[1] 廖圣[1] 郝晨钧[1] 张伟辉[1] 

机构地区：[1]哈尔滨医科大学附属第一医院普外科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2012年第2期118-120,123,共4页Journal of Harbin Medical University

摘　　要：目的研究兔急性细菌性胆囊炎不同时期的病变程度,为胆囊炎手术选择最佳时机。方法建立兔细菌性胆囊炎模型,分别于造模后3天、7天、10天进行采血化验和标本病理检查,并与对照组对比。结果对照组:胆囊结构正常;3天组:胆囊壁严重水肿,大量中性粒细胞浸润,组织质脆,易出血;7天组:胆囊壁水肿减轻,少量纤维组织增生,胆囊界限清楚,术中操作容易,出血量少;10天组,胆囊壁周围大量纤维组织增生,与周围组织黏连重,胆囊界限不清,分离困难。结论胆囊炎于发病后7天为最佳手术时机。Objective To investigate the different pathological periods of rabbits with acute bacterial cholecystitis in order to select the best time for cholecystitis surgery.Methods The model of bacterial cholecystitis of rabbits were established.The blood test was conducted and the pathological specimens were checked after 3 days,7 days and 10 days respectively,and compared with the control group.Results The control group： the cystic structures were normal;the group of 3th day： the gallbladder wall was obvious edematous,massive neutrophil infiltrated,tissue was fragile and easily bleed;the group of 7th day： edema of the gallbladder wall was alleviated,a small amount of fibrous tissue was hyperplastic,the boundary of gallbladder was clear,surgery was easy to be operated,and amount of bleeding was less;the group of 10th day： a mass of fibrous tissue around the gallbladder wall was hyperplastic,the adhesion of surrounding tissue was sever,the boundary of gallbladder was not clear,and it was difficult to be separated.Conclusion The onset of the 7th day is the best timing of surgery for cholecystitis.

关 键 词：胆囊炎 细菌性 病变 兔 

分 类 号：R575.61[医药卫生—消化系统]