喉鳞状细胞癌组织中Snail和E-cadherin的表达及其意义  

Expressions of Snail and E-cadherin in laryngeal squamous cell carcinoma tissues and their significances

作　　者：尚静[1] 房宁[1] 滕思莹[1] 崔香艳[1] 汪欣[1] 

机构地区：[1]吉林大学第一医院耳鼻咽喉-头颈外科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2012年第2期315-319,I0004,F0003,共7页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅自然科学基金资助课题(200505187)

摘　　要：目的:观察Snail和E-cadherin在喉鳞状细胞癌(LSCC)和癌旁组织中的表达情况,阐明两者与LSCC发生、发展的关系。方法:采用免疫组织化学染色技术分别检测46例患者的LSCC组织及癌旁组织中Snail和E-cadherin的表达,并将两者在LSCC中的表达情况与患者的临床病理特征进行比较,分析两者在LSCC组织中表达的相关性。结果:①Snail在LSCC和癌旁组织中表达的阳性率分别为69.57%(32/46)和36.96%(17/46),在LSCC组织中的表达阳性率明显高于癌旁组织(P<0.05);Snail在LSCC低分化组的表达阳性率明显高于高分化组和中分化组(P<0.05)。Snail的表达与LSCC的颈淋巴结转移及组织分化程度有关(P<0.05)。②E-cadherin在LSCC和癌旁组织中表达阳性率分别为47.83%(22/46)和78.30%(36/46),在LSCC组织中的表达阳性率明显低于癌旁组织(P<0.05);E-cadherin在LSCC低分化组的表达阳性率高于高分化组和中分化组(P<0.05)。E-cadherin的表达与LSCC的组织分化程度、T分级、颈淋巴结转移及临床分期有关联(P<0.01)。③LSCC组织中Snail和E-cadherin的表达呈负相关(r=-0.569 0,P<0.01)。结论:Snail和E-cadherin可能与LSCC的发生、发展密切相关,可作为判断LSCC恶性程度和预后的参考指标。Objective To observe the expressions of Snail and E-cadherin in laryngeal squamous cell carcinoma（LSCC） tissues and normal squamous epidermis tissues near cancer,and to clarify the relationship with the occurrence and development of LSCC.Methods Streptavidin peroxidase（S-P method） immunohistochemistry staining was used to detect the expressions of Snail and E-cadherin in 46 samples of LSCC and 46 samples of normal squamous epidermis near cancer.The relationship between the expressions of Snail and E-cadherin and the clinical pathological characteristics were analyzed.And the relevance of the expressions of Snail and E-cadherin in LSCC was also analyzed.Results ① The positive rates of Snail expressions in LSCC and normal squamous epidermis near cancer were 69.57%（32/46） and 36.96%（17/46）.The expression of Snail in LSCC was significantly higher than that in normal squamous epidermis near cancer（P〈0.05）.There was significant correlation between the expression of Snail in LSCC and the differentiation and cervical lymph node matastasis（P〈0.05）.②The positive rates of E-cadherin expressions in LSCC and normal squamous epidermis near cancer were 47.83%（22/46） and 78.30%（36/46）.The expression of E-cadherin in LSCC was significantly lower than that in normal squamous epidermis near cancer（P〈0.05）.There was significant correlation between the expression of E-cadherin in LSCC with the T stage,clinical stage,cervical lymph node matastasis and differentiation（P〈0.05）.③The expression of Snail in LSCC tissues was negatively correlated with the expression of Ecadherin（r=-0.569 0,P〈0.01）.Conclusion The expressions of Snail and E-cadherin may be associated with the occurrence and development of LSCC,and they could be used as the parameters which predict the malignant degree and prognosis of LSCC.

关 键 词：SNAIL E-CADHERIN 喉鳞状细胞癌 免疫组织化学 上皮-间质转化 

分 类 号：R739.65[医药卫生—肿瘤]