r-HuEPO对放射性脑损伤的防护作用  

Effect of r-HuEPO on the radiation brain injury

作　　者：高汉晶[1] 陈艳芳[2] 

机构地区：[1]天津市第四中心医院放疗科,天津300140 [2]天津医科大学第二附属医院放疗科,天津300211

出　　处：《武警医学院学报》2012年第4期248-250,共3页Acta Academiae Medicinae CPAPF

摘　　要：【目的】探讨重组体人红细胞生成素(r-HuEPO)对放射性脑损伤的防护作用。【方法】随机分组动物,每组均予单次14.5Gy全脑照射,不同的组给予不同剂量的r-HuEPO,通过丙二醛(MDA)和单细胞凝胶电泳(SCGE)来观察r-HuEPO的防护作用。【结果】r-HuEPO可减少受照射后大鼠脑组织MDA含量及循环血中淋巴细胞的DNA损伤情况。【结论】在实验观察的时间范围内,高剂量的r-HuEPO对放射性脑损伤具有一定的防护作用。【Objective】To study if r-HuEPO can decrease the brain radiation injury.【Methods】Animals divided into five groups using a random method,all groups were exposed to different U/kg r-HuEPO before single-brain irradiation,the irradiation dose was 14.5 Gy.Single Cell Gel Electrophoresis（SCGE） and Maleic Dialdehyde（MDA） were used to evaluated the protective effect.【Results】 r-HuEPO could reduce the MDA contents after irradiated.r-HuEPO can reduce circulating blood lymphocyte DNA damage.【Conclusion】The high doses of r-HuEPO had protection action in some degree to the brain radiation injury in our observation.

关 键 词：R-HUEPO 脑放射性损伤 丙二醛 单细胞凝胶电泳 

分 类 号：R774.1[医药卫生—眼科]