血清胃蛋白酶原Ⅰ、Ⅱ在萎缩性胃炎和早期胃癌诊断中的价值  

The value of PG Ⅰ,PG Ⅱ in diagnosis of atrophic gastritis and early gastric cancer

作　　者：凌鑫[1] 汤金海[1] 沈国荣[2] 沈昊[2] 杨鸿林[2] 

机构地区：[1]吴江市第一人民医院内镜中心,江苏吴江215200 [2]吴江市第一人民医院检验科,江苏吴江215200

出　　处：《临床军医杂志》2012年第2期336-338,共3页Clinical Journal of Medical Officers

摘　　要：目的通过对血清胃蛋白酶原(PG)Ⅰ、Ⅱ含量的检测,探讨血清PGⅠ、Ⅱ作为萎缩性胃炎和胃癌早期诊断标志物的可行性。方法应用化学发光法测定非萎缩性胃炎、慢性萎缩性胃炎、胃癌患者的血清PGⅠ、Ⅱ的含量并计算其比值的变化。结果与非萎缩性胃炎组相比,萎缩性胃炎组和胃癌组血清PGⅠ水平下降,差异均有统计学意义(P<0.05)。三组的PGⅡ水平比较,差异均无统计学意义(P>0.05)。萎缩性胃炎组和胃癌组PGⅠ、Ⅱ比值与非萎缩性胃炎组比较,差异有统计学意义(P<0.05)。萎缩性胃炎组和胃癌组PGⅠ,PGⅠ与PGⅡ比值比较差异无统计学意义(P>0.05)。与非萎缩性胃炎组比较,萎缩性胃炎组和胃癌组PGⅠ<70μmg/L和比值<3患者出现概率增高(P<0.05)。结论 PGⅠ、Ⅱ值及比值下降与萎缩性胃炎和胃癌发生密切相关。对胃癌的早期诊断具有重要的临床意义。Objective To analyze the feasibility of labeling atrophic gastritis and early gastric cancer with pepsinogens Ⅰ（PG Ⅰ） and pepsinogensⅡ（PG Ⅱ） according to the content determination of PG Ⅰ and PG Ⅱ.Methods We used chemical luminescence method to detected serum PGⅠ,PGⅡ in non-atrophic gastritis,atrophic gastritis,and gastric cancer patients and then calculated the changes of PGⅠ/ PGⅡ ratio.Results Compared with the non-atrophic gastritis group,the level of serum PGⅠ,PGⅡ in atrophic gastritis and gastric cancer group decreased,the difference has statistical significance（P〉0.05）.The PGⅡ level in the three groups has no statistically significant differences（P〉0.05）.The PGⅠ/PGⅡ ratio in atrophic gastritis group and gastric cancer group with the ratio in non-atrophic gastritis has statistically significant difference（P0.05）.Compared with the non-atrophic gastritis group,the probability of cases with PGⅠ〈70μmg/L and PGⅠ/PGⅡ ratio 〈3 in atrophic gastritis group and gastric cancer group increased（P〈0.05）.Conclusion The changes of PGⅠ,PGⅡ level and the decreasing of PGⅠ/PGⅡ ratio were closely related to the atrophic gastritis and gastric cancer.It plays a importment role in early diagnosis of gastric cancer.

关 键 词：血清胃蛋白酶原 萎缩性胃炎 胃肿瘤 

分 类 号：R573.32[医药卫生—消化系统]