肝癌组织中骨桥蛋白的表达与临床病理因素的相关性研究  

Correlation between the expression of OPN in hepatocellular carcinoma and the clinical pathological factors

作　　者：万幼峰[1] 许英艺[1] 张雅雅[1] 陈玉强[1] 

机构地区：[1]解放军第174医院肿瘤科,福建厦门361003

出　　处：《临床军医杂志》2012年第2期376-378,共3页Clinical Journal of Medical Officers

基　　金：2009南京军区医学科技创新项目(09MB130)

摘　　要：目的探讨骨桥蛋白(OPN)在肝癌组织中的表达与临床病理因素的关系。方法应用免疫组化法对70例肝癌组织、15例肝硬化组织和10例正常肝组织检测OPN的表达,并分析OPN的表达与临床病理因素之间的关系。结果 OPN在肝癌组织中的表达显著高于肝硬化组织及正常肝组织(P<0.01),而肝硬化组织与正常肝组织无明显差异(P>0.05);且OPN在肝癌组织中的高表达与肿瘤包膜不完整(P=0.044)及早期转移、复发(P=0.003)显著相关,而与其他临床病理因素无显著相关性。结论 OPN在肝癌组织中显著高表达,且与肿瘤包膜完整性、早期复发、转移相关。Objective To investigate the expression of osteopontin（OPN） and its correlation with clinic opathological variables in hepatocellular carcinoma.Methods Immunohistochemistry technique was used to detect the expression of OPN in 70 primary hepatocellular carcinoma tissues,15 liver cirrhosis tissues and 10 normal liver tissues.Furthermore,the correlation between OPN expression and clinicopathological variables was analyzed.Results The positive expression rate of OPN was significantly higher in tissuesfrom hepatocellular carcinoma than that in tissues from liver cirrhosis and normal liver（P0.05）.And the overexpression of OPN was significantly correlated with imperfect capsular infiltration（P=0.044） and early recurrence and metastasis（P=0.003）.Conclusion Overexpression of OPN is common in hepatocellular carcinoma and is closely related with capsular infiltration and early recurrence and metastasis.

关 键 词：骨桥蛋白 肝肿瘤 肝癌 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]