甲状腺髓样癌的临床细胞病理学分析  

Clinical analyses of medullary thyroid carcinoma through cytopathology

作　　者：康劲松[1] 钱坤[2] 刘利敏[1] 李钫[1] 赵雅桐[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院外科细胞室,武汉430030 [2]九江学院医学院附属医院病理科

出　　处：《临床血液学杂志（输血与检验）》2012年第2期221-222,共2页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:探讨甲状腺髓样癌(MTC)的临床细胞病理学特点及鉴别诊断,提高对甲状腺髓样癌的认识和诊断水平。方法:分析2例经病理组织学证实的甲状腺髓样癌的临床表现及细胞病理学特征,免疫表型。结果:例1男,56岁,右侧甲状腺结节,随吞咽活动无其他不适,镜下为梭形细胞,呈束状排列,细胞间见红染的淀粉样物,细胞病理学报告疑MTC,组织病理学诊断为MTC(梭形细胞型),免疫表型CaL(+),TG(-),NES(+);例2女,35岁,右侧甲状腺结节,质硬,随吞咽活动,镜下为圆形,椭圆形细胞,细胞质少,细胞病理学诊断考虑MTC,组织病理学诊断为MTC(小细胞型),免疫表型:CaL(-),TG(-),NES(+)。结论:充分掌握MTC的临床细胞病理学特征,结合患者的临床资料,进行总结及复习,能有效地提高诊断水平。Objective：To investigate the cytopathological features and differential diagnosis of medullary thy- roid carcinoma （MTC） in order to deeply understand the MTC and increase the rate of diagnosis. Method：Two pa- tients with MTC diagnosed by histopathological methods were used to analyze the clinical manifestation, cyto- pathological features and immunophenotype . Result： One 56 year male patient with thyroid nodule which could move with swallowing on right side was examined and diagnosed as MTC（spindle cell type） through cytopathology and histopathology examination. Under microscope, the fusiform cells were arranged in bundles. Red amyloid substance could be seen among the cells. Immunophenotype： CaL（＋）,TG（-）,NES（＋）. The other 35-year fe- male patient with hard thyroid nodule which could move with swallowing on right side was examined and diagnosed as MTC（small cell type） through cytopathology and histopathology examination. Under microscope, the cell were round or ovale and contained little cytoplasm. Immunophenotype： CaL（ - ）, TG （ - ）, NES（ ＋ ）. Conclusion： The diagnosis level might be greatly improved by sufficiently mastering the clinical cytopathology features of MTC combined with the patient＇s clinical data and analyzing them.

关 键 词：甲状腺髓样癌 临床 细胞病理学 

分 类 号：R736.1[医药卫生—肿瘤]